Break-induced replication mechanisms in yeast and mammals.
Break-induced replication mechanisms in yeast and mammals.
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DOI：
10.1016/j.gde.2021.08.002
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发表时间：
2021-12
影响因子：
4
通讯作者：
Malkova, Anna
中科院分区：
文献类型：
--
作者：
Wu, Xiaohua;Malkova, Anna
断裂诱导复制（Break induced replication，BIR）是一种专门修复双链DNA断裂的途径，该双链DNA断裂只有一端能够侵入同源模板，该同源模板可以在复制崩溃、端粒侵蚀或DNA被位点特异性内切酶切割后产生。长期以来，酵母一直是研究BIR的唯一模型系统。在酵母中的研究表明，BIR代表了一种不寻常的DNA合成模式，它由迁移的气泡驱动，并导致新合成DNA的保守遗传。这种不寻常的DNA合成类型导致高水平的突变和染色体重排。最近，在哺乳动物细胞中发现了多个BIR的例子，这使得可以比较生物体之间的BIR。最初似乎哺乳动物细胞中的BIR主要不依赖于RAD 51，因此不同于酵母中主要依赖于RAD 51的BIR。然而，一系列系统的研究，利用位点特异性DNA断裂的BIR启动哺乳动物记者导致发现高效的RAD 51依赖的BIR，允许并排比较与BIR在酵母中，这是本次审查的重点。
Break induced replication (BIR) is a pathway specialized in repair of double strand DNA breaks with only one end capable of invading homologous template that can arise following replication collapse, telomere erosion or DNA cutting by site-specific endonucleases. For a long time, yeast remained the only model system to study BIR. Studies in yeast demonstrated that BIR represents an unusual mode of DNA synthesis that is driven by a migrating bubble and leads to conservative inheritance of newly synthesized DNA. This unusual type of DNA synthesis leads to high levels of mutations and chromosome rearrangements. Recently, multiple examples of BIR were uncovered in mammalian cells that allowed the comparison of BIR between organisms. It appeared initially that BIR in mammalian cells is predominantly independent of RAD51, and therefore different from BIR that is predominantly Rad51-dependent in yeast. However, a series of systematic studies utilizing site-specific DNA breaks for BIR initiation in mammalian reporters led to the discovery of highly efficient RAD51-dependent BIR, allowing side-by side comparison with BIR in yeast which is the focus of this review.
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影响因子：
4.5
作者：
Chung WH;Zhu Z;Papusha A;Malkova A;Ira G
通讯作者：
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DOI：
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发表时间：
2008-10-14
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DOI：
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发表时间：
2010-07-02
期刊：
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DOI：
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发表时间：
2013-08-13
影响因子：
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通讯作者：
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