Pharmacologic sex hormones in pregnancy in relation to offspring obesity.
Pharmacologic sex hormones in pregnancy in relation to offspring obesity.
复制标题
妊娠期药理学性激素与后代肥胖的关系。
DOI：
10.1002/oby.20778
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发表时间：
2014-11
期刊：
影响因子：
6.9
通讯作者：
Longnecker, Matthew P.
中科院分区：
文献类型：
--
作者：
Jensen, Elizabeth T.;Longnecker, Matthew P.
评估妊娠期子宫内暴露于己烯雌酚（DES）或口服避孕药与后代肥胖之间的关系。利用1959-1974年围产期合作项目（Collaborative Perinatal Project）的数据，一项针对孕妇及其后代的多中心前瞻性研究，我们对34,419名7岁时身高和体重数据的儿童进行了超重或肥胖检查。我们使用广义线性模型来估计后代超重或肥胖（≥85百分位）或肥胖（≥95百分位）的调整优势比（aOR），根据怀孕不同月份的暴露情况。怀孕期间口服避孕药的使用与后代超重或肥胖呈正相关。妊娠头2个月肥胖的相关性最强（比值比2.0,95% CI: 1.1, 3.7）。DES的使用也与后代超重或肥胖和肥胖相关，在3-5个月开始接触时，相关性最强（例如，在3-4个月开始接触时，肥胖的aOR为2.8,95% CI: 1.3, 6.3）。妊娠期使用药理学性激素可能与儿童肥胖有关。目前尚不清楚当代低剂量口服避孕药是否也与儿童肥胖风险增加有关。
To assess the association between in utero exposure to either diethylstilbestrol (DES) or an oral contraceptive in pregnancy and offspring obesity. Using data from the Collaborative Perinatal Project (1959–1974), a multicenter prospective study of pregnant women and their offspring, we examined overweight or obesity among 34,419 children with height and weight data at age 7 years. We used generalized linear models to estimate the adjusted odds ratio (aOR) for overweight or obesity (≥85th percentile) or obesity (≥95th percentile) in the offspring according to exposure during different months of pregnancy. Oral contraceptive use during pregnancy was positively associated with offspring overweight or obesity and obesity. The magnitude of association was strongest in the first 2 months of pregnancy for obesity (aOR 2.0, 95% CI: 1.1, 3.7). DES use was also associated with offspring overweight or obesity and obesity, with the association being strongest for exposure beginning between months 3–5 (e.g., for exposure beginning in months 3–4, the aOR for obesity was 2.8, 95% CI: 1.3, 6.3). Pharmacologic sex hormone use in pregnancy may be associated with childhood obesity. Whether contemporary, lower-dose oral contraceptive formulations are similarly associated with increased risk of childhood obesity is unclear.
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影响因子：
4.8
作者：
Dieudonne, MN;Pecquery, R;Giudicelli, Y
通讯作者：
Giudicelli, Y
影响因子：
6
作者：
Palmer, Julie R.;Herbst, Arthur L.;Hoover, Robert N.
通讯作者：
Hoover, Robert N.
影响因子：
158.5
作者：
Hoover, Robert N.;Hyer, Marianne;Troisi, Rebecca
通讯作者：
Troisi, Rebecca
DOI：
10.1016/j.beem.2012.11.004
发表时间：
2013-02-01
影响因子：
7.4
作者：
Christin-Maitre, Sophie
通讯作者：
Christin-Maitre, Sophie
影响因子：
5
作者：
NISCHAN, P;EBELING, K;HIRSCH, U
通讯作者：
HIRSCH, U