Genetic Studies of Gestational Diabetes and Glucose Metabolism in Pregnancy.
Genetic Studies of Gestational Diabetes and Glucose Metabolism in Pregnancy.
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DOI：
10.1007/s11892-020-01355-3
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发表时间：
2020-11-09
影响因子：
4.2
通讯作者：
Kwak SH
中科院分区：
文献类型：
--
作者：
Powe CE;Kwak SH
本文就妊娠期糖尿病（GDM）的遗传学和妊娠期糖代谢的研究进展作一综述。我们描述了这些研究的背景下，更大的机构的文献2型糖尿病（T2D）和血糖性状基因组学。我们回顾了23项GDM的遗传关联研究，并进行了荟萃分析，结果显示在Bonferroni校正后，8个T2D基因座的变异与GDM显著相关。这些研究表明，GDM和T2D共享许多遗传风险位点。只有两个公正的全基因组关联研究（GWASs）成功揭示了妊娠期糖尿病和相关血糖性状的遗传关联。韩国妇女GWAS发现两个已知与T2D相关的基因座（靠近CDKAL 1和MTNR 1B），尽管MTNR 1B基因座与GDM的相关性似乎比T2D更强。一项针对妊娠期血糖性状的多种族GWAS发现了两个新的基因座（靠近HKDC1和BACE2），这两个基因座似乎与妊娠妇女的负荷后血糖和空腹C肽相关。目前正在努力以多基因评分的形式使用这种遗传信息来预测GDM和产后T2D的风险。研究GDM遗传相关性的文献数量有限，尤其是与现有的T2D和血糖性状基因组学文献相比。孕妇葡萄糖代谢的其他基因发现将需要更大规模的怀孕队列和国际合作努力。对这些发现的临床意义的研究也是必要的。
In this review, we summarize studies investigating genetics of gestational diabetes mellitus (GDM) and glucose metabolism in pregnancy. We describe these studies in the context of the larger body of literature on type 2 diabetes (T2D) and glycemic trait genomics. We reviewed 23 genetic association studies for GDM and performed a meta-analysis, which revealed variants at eight T2D loci significantly associated with GDM after the Bonferroni correction. These studies suggest that GDM and T2D share a number of genetic risk loci. Only two unbiased genome-wide association studies (GWASs) have successfully revealed genetic associations for GDM and related glycemic traits in pregnancy. A GWAS for GDM in Korean women identified two loci (near CDKAL1 and MTNR1B) known to be associated with T2D, though the association of the MTNR1B locus with GDM appears to be stronger than that for T2D. A multi-ethnic GWAS for glycemic traits in pregnancy identified two novel loci (near HKDC1 and BACE2) which appear to be associated with post-load glucose and fasting c-peptide specifically in pregnant women. There are ongoing efforts to use this genetic information, in the form of polygenic scores, to predict risk of GDM and postpartum T2D. The body of literature examining genetic associations with GDM is limited, especially when compared to the available literature on T2D and glycemic trait genomics. Additional genetic discovery for glucose metabolism in pregnant women will require larger pregnancy cohorts and international collaborative efforts. Studies on the clinical implications of these findings are also warranted.
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影响因子：
16.6
作者：
Guo C;Ludvik AE;Arlotto ME;Hayes MG;Armstrong LL;Scholtens DM;Brown CD;Newgard CB;Becker TC;Layden BT;Lowe WL;Reddy TE
通讯作者：
Reddy TE
影响因子：
3.5
作者：
Beaumont RN;Warrington NM;Cavadino A;Tyrrell J;Nodzenski M;Horikoshi M;Geller F;Myhre R;Richmond RC;Paternoster L;Bradfield JP;Kreiner-Møller E;Huikari V;Metrustry S;Lunetta KL;Painter JN;Hottenga JJ;Allard C;Barton SJ;Espinosa A;Marsh JA;Potter C;Zhang G;Ang W;Berry DJ;Bouchard L;Das S;Early Growth Genetics (EGG) Consortium;Hakonarson H;Heikkinen J;Helgeland Ø;Hocher B;Hofman A;Inskip HM;Jones SE;Kogevinas M;Lind PA;Marullo L;Medland SE;Murray A;Murray JC;Njølstad PR;Nohr EA;Reichetzeder C;Ring SM;Ruth KS;Santa-Marina L;Scholtens DM;Sebert S;Sengpiel V;Tuke MA;Vaudel M;Weedon MN;Willemsen G;Wood AR;Yaghootkar H;Muglia LJ;Bartels M;Relton CL;Pennell CE;Chatzi L;Estivill X;Holloway JW;Boomsma DI;Montgomery GW;Murabito JM;Spector TD;Power C;Järvelin MR;Bisgaard H;Grant SFA;Sørensen TIA;Jaddoe VW;Jacobsson B;Melbye M;McCarthy MI;Hattersley AT;Hayes MG;Frayling TM;Hivert MF;Felix JF;Hyppönen E;Lowe WL Jr;Evans DM;Lawlor DA;Feenstra B;Freathy RM
通讯作者：
Freathy RM
全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
2.7
作者：
Arora GP;Almgren P;Brøns C;Thaman RG;Vaag AA;Groop L;Prasad RB
通讯作者：
Prasad RB
影响因子：
8.2
作者：
Cho, Y. M.;Kim, T. H.;Jang, H. C.
通讯作者：
Jang, H. C.