Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma.
Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma.
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DOI：
10.1186/1756-9966-28-158
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发表时间：
2009-12-21
期刊：
影响因子：
--
通讯作者：
Aikou T
中科院分区：
文献类型：
--
作者：
Sasaki K;Natsugoe S;Ishigami S;Matsumoto M;Okumura H;Setoyama T;Uchikado Y;Kita Y;Tamotsu K;Sakamoto A;Owaki T;Aikou T
Twist是一种碱性螺旋-环-螺旋（bHLH）转录因子，已被鉴定通过调节E-钙粘蛋白表达在上皮-间质转化（EMT）介导的转移中发挥重要作用。然而，很少有人研究Twist和E-cadherin在食管鳞状细胞癌（ESCC）患者中的表达及其预后价值。本研究旨在探讨Twist和E-cadherin在食管鳞癌中的表达及其临床意义。我们用免疫组化方法研究了166例食管鳞癌原发肿瘤手术标本中它们的表达与临床病理因素包括预后之间的关系。Twist高表达率为42.0%，E-cadherin低表达率为40.4%。Twist高表达和E-cadherin低表达与肿瘤浸润深度、淋巴结转移、远处淋巴结转移、临床分期、淋巴结转移及预后不良有关。Twist高表达与E-cadherin表达降低显著相关。在保留E-cadherin组中，Twist表达低的患者的5年生存率高于Twist表达高的患者。多因素分析显示Twist低表达和E-cadherin表达与肿瘤深度、远处淋巴结转移和E-cadherin表达沿着是独立的预后因素。Twist和E-cadherin表达的评估对于确定ESCC患者的肿瘤特性，包括预后是有用的。
Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cadherin expression. However, few authors have examined the expression of Twist and E-cadherin and their prognostic value in patients with esophageal squamous cell carcinoma (ESCC). The purpose of this study is to evaluate the clinical significance of Twist and E-cadherin expression in ESCC. We immunohistochemically investigated the relationship between their expression and clinicopathological factors including prognosis in surgical specimens of primary tumors in 166 patients with ESCC. The expression rate of high Twist was 42.0% and that of preserved E-cadherin was 40.4%. The expression of high Twist and reduced E-cadherin was significantly associated with depth of tumor invasion, lymph node metastasis, distant nodal metastasis, stage and lymphatic invasion, and poor prognosis. High Twist expression significantly correlated with reduced E-cadherin expression. In the preserved E-cadherin group, the 5-year survival rate was better for patients who were low for Twist expression than for those who were high for Twist expression. Multivariate analysis indicated that the combination of low Twist and preserved E-cadherin expression was an independent prognostic factor along with tumor depth, distant nodal metastasis and E-cadherin expression. Evaluation of Twist and E-cadherin expressions should be useful for determining tumor properties, including prognosis, in patients with ESCC.
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影响因子：
64.5
作者：
Yang, J;Mani, SA;Weinberg, RA
通讯作者：
Weinberg, RA
影响因子：
6.4
作者：
Entz-Werlé, N;Stoetzel, C;Perrin-Schmitt, F
通讯作者：
Perrin-Schmitt, F
影响因子：
6
作者：
Rosivatz, E;Becker, I;Becker, KF
通讯作者：
Becker, KF
DOI：
10.1073/pnas.0703900104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Mani, Sendurai A.;Yang, Jing;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.
影响因子：
3.4
作者：
Yuen, Hiu-Fung;Chan, Yuen-Piu;Chan, Kwok-Wah
通讯作者：
Chan, Kwok-Wah