The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage.
The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage.
复制标题
染色质重塑蛋白 SMARCAD1/Fun30 响应 DNA 损伤的机制
DOI：
10.3389/fcell.2020.560098
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Li JB
中科院分区：
文献类型：
--
作者：
Tong ZB;Ai HS;Li JB
在真核生物中，DNA包裹在高度浓缩的染色质中以组织基因组，但闭塞了许多调控DNA元件。因此，在细胞中转录、复制和DNA修复等多种生物过程都需要进入核小体内的DNA。为了解决这个问题，细胞使用一组特殊的atp依赖性染色质重塑蛋白复合物来动态访问包装的DNA。在这篇综述中，我们总结了近年来关于一个特殊的染色质重塑剂SMARCAD1Fun30的功能和机制研究的最新进展，SMARCAD1Fun30已被证明在不同的细胞过程中发挥关键作用，并受到近年来的广泛关注。重点关注SMARCAD1Fun30如何通过其染色质重塑活性调控各种细胞过程，特别是SMARCAD1Fun30在基因表达控制、异染色质维持和建立以及DNA损伤修复中的调节作用。此外，我们还综述了SMARCAD1Fun30促进双链断裂端DNA末端切除的分子机制，包括招募机制、活性调控机制和染色质重塑机制。
DNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription, replication, and DNA repair. To cope with this problem, cells employ a set of specialized ATP-dependent chromatin-remodeling protein complexes to enable dynamic access to packaged DNA. In the present review, we summarize the recent advances in the functional and mechanistic studies on a particular chromatin remodeler SMARCAD1Fun30 which has been demonstrated to play a key role in distinct cellular processes and gained much attention in recent years. Focus is given to how SMARCAD1Fun30 regulates various cellular processes through its chromatin remodeling activity, and especially the regulatory role of SMARCAD1Fun30 in gene expression control, maintenance and establishment of heterochromatin, and DNA damage repair. Moreover, we review the studies on the molecular mechanism of SMARCAD1Fun30 that promotes the DNA end-resection on double-strand break ends, including the mechanisms of recruitment, activity regulation and chromatin remodeling.
登录
查看更多内容
影响因子：
64.8
作者：
Ayala R;Willhoft O;Aramayo RJ;Wilkinson M;McCormack EA;Ocloo L;Wigley DB;Zhang X
通讯作者：
Zhang X
使用化学合成的泛素化组蛋白检查 USP51 的去泛素化位点选择性
影响因子：
3.2
作者：
Ai, Huasong;Guo, Yu;Liu, Lei
通讯作者：
Liu, Lei
影响因子：
64.8
作者：
Costelloe, Thomas;Louge, Raphael;Tomimatsu, Nozomi;Mukherjee, Bipasha;Martini, Emmanuelle;Khadaroo, Basheer;Dubois, Kenny;Wiegant, Wouter W.;Thierry, Agnes;Burma, Sandeep;van Attikum, Haico;Llorente, Bertrand
通讯作者：
Llorente, Bertrand
影响因子：
7
作者：
Chen, Zhen;Tran, Mykim;Chen, Junjie
通讯作者：
Chen, Junjie
影响因子：
4.4
作者：
Adra, CN;Donato, JL;Drews, R
通讯作者：
Drews, R