Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment.
Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment.
复制标题
代谢重编程诱导肿瘤微环境中的巨噬细胞极化
DOI：
10.3389/fimmu.2022.840029
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
巨噬细胞是天然免疫系统中最重要的细胞之一，在不同的微环境刺激下，可转化为两种分子表型和功能特征完全不同的亚型：干扰素-γ/脂多糖诱导的M1巨噬细胞和IL-4/IL-10/IL-13诱导的M2巨噬细胞。肿瘤相关巨噬细胞(TAMs)通过肿瘤微环境(TME)中的各种因素与巨噬细胞相区别。TAMs具有M2巨噬细胞的表型和功能，能够分泌多种细胞因子促进肿瘤进展。肿瘤细胞和巨噬细胞都可以通过代谢重编程来满足细胞快速生长和增殖的能量需求，因此全面了解的促肿瘤和抗肿瘤代谢开关对于了解免疫逃逸机制至关重要。本文重点介绍了巨噬细胞极化和代谢重编程过程中相关信号通路和细胞因子的作用，并简要讨论了不同微环境和巨噬细胞致病性的影响，以及针对某些代谢和极化信号通路的抑制药物的研究进展。
Macrophages are one of the most important cells in the innate immune system, they are converted into two distinct subtypes with completely different molecular phenotypes and functional features under different stimuli of the microenvironment: M1 macrophages induced by IFN-γ/lipopolysaccharides(LPS) and M2 macrophages induced by IL-4/IL-10/IL-13. Tumor-associated macrophages (TAMs) differentiate from macrophages through various factors in the tumor microenvironment (TME). TAMs have the phenotype and function of M2 macrophages and are capable of secreting multiple cytokines to promote tumor progression. Both tumor cells and macrophages can meet the energy needs for rapid cell growth and proliferation through metabolic reprogramming, so a comprehensive understanding of pro-tumor and antitumor metabolic switches in TAM is essential to understanding immune escape mechanisms. This paper focuses on the functions of relevant signaling pathways and cytokines during macrophage polarization and metabolic reprogramming, and briefly discusses the effects of different microenvironments and macrophage pathogenicity, in addition to describing the research progress of inhibitory drugs for certain metabolic and polarized signaling pathways.
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影响因子：
5.6
作者：
Boutilier AJ;Elsawa SF
通讯作者：
Elsawa SF
影响因子：
4.4
作者：
Abe H;Semba H;Takeda N
通讯作者：
Takeda N
DOI：
10.1158/1078-0432.ccr-19-3890
发表时间：
2020-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cowman SJ;Fuja DG;Liu XD;Tidwell RSS;Kandula N;Sirohi D;Agarwal AM;Emerson LL;Tripp SR;Mohlman JS;Stonhill M;Garcia G;Conley CJ;Olalde AA;Sargis T;Ramirez-Torres A;Karam JA;Wood CG;Sircar K;Tamboli P;Boucher K;Maughan B;Spike BT;Ho TH;Agarwal N;Jonasch E;Koh MY
通讯作者：
Koh MY
影响因子：
8.8
作者：
Bae S;Park PSU;Lee Y;Mun SH;Giannopoulou E;Fujii T;Lee KP;Violante SN;Cross JR;Park-Min KH
通讯作者：
Park-Min KH
影响因子：
7.3
作者：
Chávez-Galán L;Olleros ML;Vesin D;Garcia I
通讯作者：
Garcia I