Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making.
Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making.
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DOI:
10.1038/s41593-020-0696-5
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发表时间:
2020-11
影响因子:
25
通讯作者:
Pillow JW
中科院分区:
文献类型:
--
作者:
Aoi MC;Mante V;Pillow JW
Recent work has suggested that prefrontal cortex (PFC) plays a key role in context-dependent perceptual decision-making. Here we address that role using a new method for identifying task-relevant dimensions of neural population activity. Specifically, we show that PFC has a multi-dimensional code for context, decisions, and both relevant and irrelevant sensory information. Moreover, these representations evolve in time, with an early linear accumulation phase followed by a phase with rotational dynamics. We identify the dimensions of neural activity associated with these phases, and show that they do not arise from distinct populations, but of a single population with broad tuning characteristics. Finally, we use model-based decoding to show that the transition from linear to rotational dynamics coincides with a plateau in decoding accuracy, revealing that rotational dynamics in PFC preserve sensory choice information for the duration of the stimulus integration period.
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DOI:
10.1126/science.aaa4056
发表时间:
2015-07-10
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Latimer KW;Yates JL;Meister ML;Huk AC;Pillow JW
通讯作者:
Pillow JW
影响因子:
25
作者:
Elsayed GF;Cunningham JP
通讯作者:
Cunningham JP
影响因子:
16.2
作者:
Beck JM;Ma WJ;Kiani R;Hanks T;Churchland AK;Roitman J;Shadlen MN;Latham PE;Pouget A
通讯作者:
Pouget A
影响因子:
3.7
作者:
Ding, Long;Gold, Joshua I.
通讯作者:
Gold, Joshua I.
影响因子:
16.2
作者:
Heitz RP;Schall JD
通讯作者:
Schall JD