Large-scale generation of differentiated cells to achieve regenerative medicine.

Large-scale generation of differentiated cells to achieve regenerative medicine.
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DOI:
10.1186/scrt399
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发表时间:
2014-01-20
影响因子:
7.5
通讯作者:
Sasaki K
Sasaki K
中科院分区:
医学2区
文献类型:
--
作者:
Sasaki K

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微重力和流体动力学应力对多能干细胞产生的拟胚体的影响诱导并指导其分化。利用这种流体动力学效应,结合外源性因子和三维培养,已经开发出一种新的技术来生产功能,有效和安全的肝细胞用于移植。这项技术的发展将导致大量分化细胞的自动化生产,并将大大有助于再生医学。
The effects of microgravity and fluid dynamic stress on embryoid bodies generated from pluripotent stem cells induce and direct their differentiation. Using this hydrodynamic effect combined with exogenous factors and three-dimensional culture, a new technique has been developed to produce functional, effective, and safe hepatocytes for transplantation. The evolution of this technique will lead to automated production of a large number of differentiated cells and will significantly contribute to regenerative medicine.
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