Conceptus implantation and placentation: molecules related to epithelial–mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes
Conceptus implantation and placentation: molecules related to epithelial–mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes
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概念植入和胎盘：上皮相关分子
DOI：
10.1007/s12522-015-0215-7
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发表时间：
2016
影响因子：
3.4
通讯作者：
Kusama K
中科院分区：
文献类型：
--
作者：
Imakawa K;Bai R;Fujiwara H;Kusama K
哺乳动物生殖所特有的概念着床和胎盘形成过程已被广泛研究。人们曾经认为这些事件的过程差异很大，特别是在植入和/或胎盘的侵入性和非侵入性模式之间。然而，无论采用何种植入方式，受精体植入母体子宫内膜的生理生化过程（包括基因表达的种类及其产物）现在被认为没有太大差异。最近的进展表明，除了经典表征的激素、细胞因子、蛋白酶和细胞粘附分子外，上皮-间质转化、与淋巴细胞归巢相关的分子、内源性逆转录病毒的表达以及可能的外泌体都是从概念着床到胎盘的进展所必需的。因此，在本次综述中，与这些事件相关的新发现被纳入母体子宫内膜受孕的背景中。
Processes of conceptus implantation and placentation, unique to mammalian reproduction, have been extensively studied. It was once thought that processes of these events varied greatly, notably between invasive and noninvasive modes of implantation and/or placentation. Regardless of the mode of implantation, however, physiological and biochemical processes in conceptus implantation to the maternal endometrium including the kinds of gene expression and their products are now considered not to differ so much. Recent progress has identified that in addition to the hormones, cytokines, proteases and cell adhesion molecules classically characterized, epithelial–mesenchymal transition, molecules related to lymphocyte homing, the expression of endogenous retroviruses and possibly exosomes are all required for the progression of conceptus implantation to placentation. In this review, therefore, new findings related to these events are integrated into the context of conceptus implantation to the maternal endometrium.
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