Phospholipid turnover and acyl chain remodeling in the yeast ER.
Phospholipid turnover and acyl chain remodeling in the yeast ER.
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DOI：
10.1016/j.bbalip.2019.05.006
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发表时间：
2020-01
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影响因子：
--
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磷脂的周转通过影响脂质头部基团和酰基链组成在膜脂质稳态中起着重要作用。本文综述了参考真核生物酿酒酵母内质网膜中主要磷脂类的降解和酰基链重塑，即磷脂酰胆碱（PC），磷脂酰肌醇（PI）和磷脂酰乙醇胺（PE）。介绍了磷脂周转反应，简要概述了磷脂重构在高等真核生物中的发生及其重要作用。磷脂酰基链交换的既定机制的库存后，磷脂降解和重塑的磷脂酶和酰基转移酶定位于酵母ER的当前知识进行了总结。PC经历PC脱酰-再酰化重塑途径（PC-DRP），该途径涉及磷脂酶B、最近鉴定的甘油磷酸胆碱酰基转移酶Gpc 1 p和广泛特异性酰基转移酶Ale 1 p。PI通过涉及Cst 26 p的重构反应在合成后富集C18：0酰基链。PE可以通过磷脂：二酰基甘油酰基转移酶Lro 1 p进行周转，作为酰基链重塑的第一步。线索磷脂酰基链重塑的功能进行了讨论。
The turnover of phospholipids plays an essential role in membrane lipid homeostasis by impacting both lipid head group and acyl chain composition. This review focusses on the degradation and acyl chain remodeling of the major phospholipid classes present in the ER membrane of the reference eukaryote Saccharomyces cerevisiae, i.e. phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidylethanolamine (PE). Phospholipid turnover reactions are introduced, and the occurrence and important functions of phospholipid remodeling in higher eukaryotes are briefly summarized. After presenting an inventory of established mechanisms of phospholipid acyl chain exchange, current knowledge of phospholipid degradation and remodeling by phospholipases and acyltransferases localized to the yeast ER is summarized. PC is subject to the PC deacylation-reacylation remodeling pathway (PC-DRP) involving a phospholipase B, the recently identified glycerophosphocholine acyltransferase Gpc1p, and the broad specificity acyltransferase Ale1p. PI is post-synthetically enriched in C18:0 acyl chains by remodeling reactions involving Cst26p. PE may undergo turnover by the phospholipid: diacylglycerol acyltransferase Lro1p as first step in acyl chain remodeling. Clues as to the functions of phospholipid acyl chain remodeling are discussed.
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影响因子：
4.8
作者：
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通讯作者：
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DOI：
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