Community transmission of SARS-CoV-2 during the Delta wave in New York City.
Community transmission of SARS-CoV-2 during the Delta wave in New York City.
复制标题
DOI：
10.1186/s12879-023-08735-6
复制
发表时间：
2023-11-02
影响因子：
3.7
通讯作者：
Pei, Sen
中科院分区：
文献类型：
--
作者：
Dai, Katherine;Foerster, Steffen;Vora, Neil;Blaney, Kathleen;Keeley, Chris;Hendricks, Lisa;Varma, Jay;Long, Theodore;Shaman, Jeffrey;Pei, Sen
了解SARS-CoV-2变异体的社区传播对于后大流行时代的疾病控制至关重要。Delta变体（B.1.617.2）于2020年底出现，并于2021年夏季成为全球主要VOC。虽然Delta变异的流行病学特征已被广泛研究，但这些特征如何影响城市环境中的社区传播仍然知之甚少。利用高分辨率接触者追踪数据和检测记录，我们分析了2021年5月至2021年10月纽约市（NYC）内Delta波期间SARS-CoV-2的传播情况。我们在个人层面和177个邮政编码区重建了传播网络，检查了网络结构和空间传播模式，并使用统计分析来估计与COVID-19传播相关的因素的影响。我们发现相当大的个体差异，报告的接触和继发感染，符合前三角洲时期。与早期波相比，三角洲周期有更频繁的跨越邮政编码的长距离传输事件。通过使用邮政编码级别的社会经济、流动性和COVID-19监测数据，我们发现，邮政编码区域的累积病例数越多，邮政编码内和邮政编码间的传播就越少，每个邮政编码的游客数量与通过接触者追踪和检测发现的非家庭感染数量呈正相关。Delta变体在纽约市邮政编码区域产生了更大的长距离空间传输，这可能是由于其在研究期间增加了传输率和提高了人类流动性。我们的研究结果强调了人群免疫力在减少VOCs传播方面的潜在作用。量化免疫力的变异性对于识别未来易受VOC影响的亚群至关重要。此外，限制人类流动性的非药物干预可能会减少SARS-CoV-2在连续大流行波中的传播，应鼓励减少未来VOC的传播。在线版本包含补充材料，可通过10.1186/s12879-023-08735-6获得。
Understanding community transmission of SARS-CoV-2 variants of concern (VOCs) is critical for disease control in the post pandemic era. The Delta variant (B.1.617.2) emerged in late 2020 and became the dominant VOC globally in the summer of 2021. While the epidemiological features of the Delta variant have been extensively studied, how those characteristics shaped community transmission in urban settings remains poorly understood. Using high-resolution contact tracing data and testing records, we analyze the transmission of SARS-CoV-2 during the Delta wave within New York City (NYC) from May 2021 to October 2021. We reconstruct transmission networks at the individual level and across 177 ZIP code areas, examine network structure and spatial spread patterns, and use statistical analysis to estimate the effects of factors associated with COVID-19 spread. We find considerable individual variations in reported contacts and secondary infections, consistent with the pre-Delta period. Compared with earlier waves, Delta-period has more frequent long-range transmission events across ZIP codes. Using socioeconomic, mobility and COVID-19 surveillance data at the ZIP code level, we find that a larger number of cumulative cases in a ZIP code area is associated with reduced within- and cross-ZIP code transmission and the number of visitors to each ZIP code is positively associated with the number of non-household infections identified through contact tracing and testing. The Delta variant produced greater long-range spatial transmission across NYC ZIP code areas, likely caused by its increased transmissibility and elevated human mobility during the study period. Our findings highlight the potential role of population immunity in reducing transmission of VOCs. Quantifying variability of immunity is critical for identifying subpopulations susceptible to future VOCs. In addition, non-pharmaceutical interventions limiting human mobility likely reduced SARS-CoV-2 spread over successive pandemic waves and should be encouraged for reducing transmission of future VOCs. The online version contains supplementary material available at 10.1186/s12879-023-08735-6.
登录
查看更多内容
影响因子：
3.4
作者：
Rushworth, Alastair;Lee, Duncan;Mitchell, Richard
通讯作者：
Mitchell, Richard
影响因子：
82.9
作者：
He, Xi;Lau, Eric H. Y.;Leung, Gabriel M.
通讯作者：
Leung, Gabriel M.
影响因子：
16.6
作者：
Hu S;Wang W;Wang Y;Litvinova M;Luo K;Ren L;Sun Q;Chen X;Zeng G;Li J;Liang L;Deng Z;Zheng W;Li M;Yang H;Guo J;Wang K;Chen X;Liu Z;Yan H;Shi H;Chen Z;Zhou Y;Sun K;Vespignani A;Viboud C;Gao L;Ajelli M;Yu H
通讯作者：
Yu H
DOI：
10.1016/j.ajpath.2021.10.019
发表时间：
2022-03
期刊：
The American journal of pathology
影响因子：
--
作者：
Christensen PA;Olsen RJ;Long SW;Subedi S;Davis JJ;Hodjat P;Walley DR;Kinskey JC;Ojeda Saavedra M;Pruitt L;Reppond K;Shyer MN;Cambric J;Gadd R;Thakur RM;Batajoo A;Mangham R;Pena S;Trinh T;Yerramilli P;Nguyen M;Olson R;Snehal R;Gollihar J;Musser JM
通讯作者：
Musser JM
影响因子：
64.8
作者：
Planas, Delphine;Veyer, David;Schwartz, Olivier
通讯作者：
Schwartz, Olivier