Variation in dicer gene is associated with increased survival in T-cell lymphoma.
Variation in dicer gene is associated with increased survival in T-cell lymphoma.
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Dicer 基因的变异与 T 细胞淋巴瘤的存活率增加有关。
DOI：
10.1371/journal.pone.0051640
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Li X;Tian X;Zhang B;Zhang Y;Chen J
DICER是RNase III家族中的一种内切酶，在RNA干扰(RNAi)途径中起着至关重要的作用。在包括某些亚型的T细胞淋巴瘤(TCL)在内的多种肿瘤中都有表达异常，这影响了患者的预后。单核苷酸多态(SNP)rs3742330A>；G已在DICER基因的3‘非翻译区(3’非翻译区)被发现，该区域对mRNA转录的稳定性起重要作用。我们调查了163例TCL患者中rs3742330是否与生存有关。Disher rs3742330与TCL的存活率显著相关。携带GG基因(n = 12)的患者总生存期(OS)显著高于携带GA和AA基因的患者(n = 70和n = 81；p = 0.031)。此外，在成熟T型患者中保持了显著的相关性(n = 134；p = 0.026)。在多变量COX回归分析中，rs3742330与常用的国际预后指数和BAFF rs9514828一起被证明是OS的独立预测因子，我们先前报道的另一种SNP rs9514828与TCL生存相关，GA基因型患者死亡率的风险比(HR)为8.956(95%CI，1.210~66.318；p = 0.032)，AA基因型患者死亡率的风险比(HR)为10.145(95%CI，1.371~75.084；p = 0.023)。此外，我们还观察了Disher rs3742330和BAFF rs9514828对TCL存活率的累积影响。与携带0个不良基因的患者相比，携带1个和2个不良基因的患者死亡风险增加，HR分别为7.104(95%CI，0.969~53.086；p = 0.054)和14.932(95%CI，1.950~114.354；p = 0.009)，且有明显的剂量-反应趋势(P趋势 = 0.004)。综上所述，Disher rs3742330基因与TCL患者的生存相关，提示基因变异可能对TCL患者的预后有一定的预测作用。
Dicer, an endonuclease in RNase III family, is essential for the RNA interference (RNAi) pathway. Aberrant expression of Dicer has been shown in various cancers including some subtypes of T cell lymphoma (TCL), which influences patient prognosis. A single-nucleotide polymorphism (SNP) rs3742330A>G has been identified in the Dicer gene, located in the 3′ untranslated region (3′ UTR) that is important for mRNA transcript stability. We investigated whether rs3742330 is associated with the survival in 163 TCL patients. Significant association between Dicer rs3742330 and TCL survival were found. Patients carrying the GG genotype (n = 12) had a significantly increased overall survival (OS) compared with those carrying the GA and AA genotypes (n = 70 and n = 81, respectively; p = 0.031). Moreover, the significant association was maintained for patients with mature T type (n = 134; p = 0.026). In multivariate Cox-regression analysis, rs3742330 proved to be an independent predictor for OS, together with the commonly used International Prognostic Index (IPI) and BAFF rs9514828, another SNP we have previously reported to be associated with TCL survival, with hazard ratios (HRs) for patient death rate of 8.956 (95% CI, 1.210 to 66.318; p = 0.032) for the GA genotype and 10.145 (95% CI, 1.371 to 75.084; p = 0.023) for the AA genotype. Furthermore, we observed cumulative effects of Dicer rs3742330 and BAFF rs9514828 on TCL survival. Compared with patients carrying zero unfavorable genotype, those carrying one and two unfavorable genotypes had an increased risk of death with a HR of 7.104 (95% CI, 0.969–53.086; p = 0.054) and 14.932 (95% CI, 1.950–114.354; p = 0.009), respectively, with a significant dose-response trend (ptrend = 0.004). In conclusion, Dicer rs3742330 is associated with TCL survival, suggesting that genetic variation might play a role in predicting prognosis of TCL patients.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
影响因子：
4.6
作者：
Clague, Jessica;Lippman, Scott M.;Yang, Hushan;Hildebrandt, Michelle A. T.;Ye, Yuanqing;Lee, J. Jack;Wu, Xifeng
通讯作者：
Wu, Xifeng
影响因子：
3.7
作者：
Ibarrola-Villava, Maider;Fernandez, Lara P.;Ribas, Gloria
通讯作者：
Ribas, Gloria
DOI：
10.1158/1078-0432.ccr-09-1736
发表时间：
2010-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Landi MT;Zhao Y;Rotunno M;Koshiol J;Liu H;Bergen AW;Rubagotti M;Goldstein AM;Linnoila I;Marincola FM;Tucker MA;Bertazzi PA;Pesatori AC;Caporaso NE;McShane LM;Wang E
通讯作者：
Wang E
影响因子：
5.7
作者：
Karube, Y;Tanaka, H;Takahashi, T
通讯作者：
Takahashi, T