Redox regulation of neuronal voltage-gated calcium channels.
Redox regulation of neuronal voltage-gated calcium channels.
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神经元电压门控钙通道的氧化还原调节。
DOI：
10.1089/ars.2013.5610
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发表时间：
2014
影响因子：
6.6
通讯作者：
Jevtovic-Todorovic,Vesna
中科院分区：
文献类型：
--
作者：
Todorovic,SlobodanM;Jevtovic-Todorovic,Vesna
电压门控性钙通道在神经元中广泛表达，是细胞兴奋性和突触递质释放的关键调节因子。越来越多的证据表明，多种亚型的电压门控钙通道可能受到氧化和还原的调节。最近的研究进展：一些研究已经证实电压门控钙通道的T型和高压激活亚型都可以被氧化还原调节。本文综述了不同的机制，可以参与氧化还原调节的钙通道功能和它们在神经元功能的影响，特别是在疼痛通路和丘脑oscillation.Critical问题：目前在该领域的关键问题是破译钙通道modulationviaredox反应的精确机制。在这篇综述中，我们讨论了共价翻译后修饰viaoxidation的半胱氨酸分子和螯合的痕量金属，和涉及一氧化氮相关分子和自由基的反应。氧化还原为基础的反应在电压门控钙通道的调节的作用的认识提高，可能会导致新的氧化还原机制在生理和病理processes.Future Directions的认识提高：电压门控钙通道的氧化还原机制和网站的识别可能允许开发新的和特定的离子通道治疗未满足的医疗需求。因此，它可能是可能的，以调节这些通道的氧化还原状态在治疗病理过程，如癫痫和神经性疼痛。抗氧化剂。Redox Signal.21，880-891.
Significance:Voltage-gated calcium channels are ubiquitously expressed in neurons and are key regulators of cellular excitability and synaptic transmitter release. There is accumulating evidence that multiple subtypes of voltage-gated calcium channels may be regulated by oxidation and reduction. However, the redox mechanisms involved in the regulation of channel function are not well understood.Recent Advances:Several studies have established that both T-type and high-voltage-activated subtypes of voltage-gated calcium channel can be redox-regulated. This article reviews different mechanisms that can be involved in redox regulation of calcium channel function and their implication in neuronal function, particularly in pain pathways and thalamic oscillation.Critical Issues:A current critical issue in the field is to decipher precise mechanisms of calcium channel modulationviaredox reactions. In this review we discuss covalent post-translational modificationviaoxidation of cysteine molecules and chelation of trace metals, and reactions involving nitric oxide-related molecules and free radicals. Improved understanding of the roles of redox-based reactions in regulation of voltage-gated calcium channels may lead to improved understanding of novel redox mechanisms in physiological and pathological processes.Future Directions:Identification of redox mechanisms and sites on voltage-gated calcium channel may allow development of novel and specific ion channel therapies for unmet medical needs. Thus, it may be possible to regulate the redox state of these channels in treatment of pathological process such as epilepsy and neuropathic pain.Antioxid. Redox Signal.21, 880–891.
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DOI：
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期刊：
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DOI：
10.1016/s0140-6736(77)91762-7
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期刊：
The Lancet
影响因子：
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影响因子：
4.4
作者：
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DOI：
10.1016/s0300-595x(79)80048-1
发表时间：
1979
期刊：
Clinics in Endocrinology and Metabolism
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