Oral contraceptive use may protect against low bone mass
Oral contraceptive use may protect against low bone mass
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使用口服避孕药可预防低骨量
DOI：
10.1001/archinte.1991.00400100053009
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发表时间：
1991
影响因子：
39
通讯作者：
C. Johnson
中科院分区：
文献类型：
--
作者：
M. Kleerekoper;R. Brienza;Lonni Schultz;C. Johnson
这项横断面回顾性流行病学研究调查了2297名妇女的低骨密度(BMD)危险因素，其中76%是绝经后妇女。1986年和1987年向12个骨质疏松症筛查中心提交的妇女提供了生殖信息、口服避孕药使用史、骨密度测量和其他数据。每个女性都根据各自中心的骨密度测量范围被归类为骨密度类别。绝经、年龄和绝经年限的增加以及体重指数的下降与低BMD有关。口服避孕药使用史对低骨密度有保护作用(优势比=0.35，95%可信区间=0.23~0.53)。多变量分析证实了这一结果，并进一步证明，延长使用时间是有保护作用的。这些数据表明，事先使用口服避孕药与较高的BMD水平有关，而较低BMD的保护程度与暴露时间有关。(ARCH实习生Med.1991年；151：1971-1976)
This cross-sectional retrospective epidemiologic study investigated risk factors for low bone mineral density (BMD) in a group of 2297 women, 76% of whom were postmenopausal. Reproductive information, history of oral contraceptive use, BMD measurements, and other data were available from women presenting to 12 osteoporosis screening centers in 1986 and 1987. Each woman was classified into a BMD category based on the range of BMD measurements at her respective center. Menopause, increasing age and years since menopause, and decreasing body mass index were associated with low BMD. A history of oral contraceptive use was protective against low BMD (odds ratio = 0.35, 95% confidence interval = 0.23 to 0.53). Multivariate analyses confirmed this result and further demonstrated that increasing duration of use was protective. These data suggest that prior use of oral contraceptive agents is associated with higher levels of BMD and that the degree of protection from lower BMD is related to duration of exposure. (Arch Intern Med. 1991;151:1971-1976)
影响因子：
158.5
作者：
RICHELSON, LS;WAHNER, HW;RIGGS, BL
通讯作者：
RIGGS, BL
影响因子：
39.2
作者：
ETTINGER, B;GENANT, HK;CANN, CE
通讯作者：
CANN, CE