Elevated serum lipids in veterans with combat-related chronic posttraumatic stress disorder.
Elevated serum lipids in veterans with combat-related chronic posttraumatic stress disorder.
复制标题
患有与战斗相关的慢性创伤后应激障碍的退伍军人血脂升高。
DOI：
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复制
发表时间：
2002
影响因子：
1.9
通讯作者：
Danijel Crnković
中科院分区：
文献类型：
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作者：
V. Solter;V. Thaller;D. Karlovic;Danijel Crnković
目的
评估血清胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯、动脉硬化指数、确定的动脉硬化危险因子（ERF），根据成人治疗小组III（ATP-III），患有与战斗有关的创伤后应激障碍（PTSD）的退伍军人之间的冠心病风险和10年风险对照组为重度抑郁症患者。
方法
我们使用酶分析法测定了103例PTSD患者和92例重度抑郁症患者的血清胆固醇、LDL-C、HDL-C和甘油三酯。根据胆固醇、LDL-C和HDL-C水平计算AI、ERF和ATP-III。两组在年龄和体重指数（BMI）上相匹配。选择重度抑郁症患者作为对照组，因为他们没有血脂的变化。
结果
与战斗有关的PTSD患者的平均胆固醇浓度较高，（6.2+/-1.1 mmol/L vs 5.3+/-0.9 mmol/L; p<0.001），LDL-C（3.9 ± 0.7 mmol/L vs 3.5 ± 1.0 mmol/L; p = 0.005）和甘油三酯（2.9+/-2.3 mmol/L vs 1.5+/-0.5 mmol/L; p<0.001），HDL-C（1.0+/-0.3 mmol/L vs 1.3+/-0.2 mmol/L; p<0.001）低于对照组。与对照组相比，PTSD患者的动脉硬化指数（4.2+/-1.2 vs 3.7+/-1.7; p = 0.050）、ERF（6.4+/-1.9 vs 5.5+/-2.4; p = 0.010）和ATP-III（12.1+/-3.3 vs 10.2+/-3.8; p<0.001）更高。
结论
血清脂质浓度升高与战斗相关的PTSD有关。这可能意味着与战斗有关的PTSD患者患动脉硬化的风险更高。
AIM
To assess possible differences in serum cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, arteriosclerosis index, established risk factor (ERF) of arteriosclerosis, and 10-year risk for coronary disease according to the Adult Treatment Panel III (ATP-III) between veterans with combat-related posttraumatic stress disorder (PTSD) and a control group consisting of patients with major depressive disorder.
METHOD
We determined serum cholesterol, LDL-C, HDL-C, and triglycerides in the patients with PTSD (n = 103) and patients with major depressive disorder (n = 92), using the enzyme-assay method. AI, ERF, and ATP-III were calculated from cholesterol, LDL-C, and HDL-C levels. The groups were matched in age and body mass index (BMI). Patients with major depressive disorder were chosen as a control group because they do not have changes in serum lipids.
RESULTS
Patients with combat-related PTSD had higher mean concentration of cholesterol (6.2+/-1.1 mmol/L vs 5.3+/-0.9 mmol/L; p<0.001), LDL-C (3.9+/-0.7 mmol/L vs 3.5+/-1.0 mmol/L; p = 0.005), and triglycerides (2.9+/-2.3 mmol/L vs 1.5+/-0.5 mmol/L; p<0.001), and lower HDL-C (1.0+/-0.3 mmol/L vs 1.3+/-0.2 mmol/L; p<0.001) than the control group. Arteriosclerosis index (4.2+/-1.2 vs 3.7+/-1.7; p = 0.050), ERF (6.4+/-1.9 vs 5.5+/-2.4; p = 0.010), and ATP-III (12.1+/-3.3 vs 10.2+/-3.8; p<0.001) were higher in PTSD than in the control group.
CONCLUSION
Elevated concentrations of serum lipids are associated with combat-related PTSD. This may imply that patients with combat-related PTSD are under a higher risk for arteriosclerosis.
影响因子：
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作者：
R. Yehuda;David Boisoneau;M. Lowy;E. Giller
通讯作者：
R. Yehuda;David Boisoneau;M. Lowy;E. Giller
恐慌症患者的胆固醇水平较高。
DOI：
10.1176/ajp.149.3.376
发表时间：
1992
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bajwa,WK;Asnis,GM;Sanderson,WC;Irfan,A;vanPraag,HM
通讯作者：
vanPraag,HM
创伤后应激障碍中的去甲肾上腺素能和血清素能功能。
影响因子：
--
作者：
Southwick,SM;Krystal,JH;Bremner,JD;Morgan3rd,CA;Nicolaou,AL;Nagy,LM;Johnson,DR;Heninger,GR;Charney,DS
通讯作者：
Charney,DS