Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications.
Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications.
复制标题
基于阿奇霉素的广谱抗生素预防对非感染性剖宫产伤口并发症的影响。
DOI：
10.1055/s-0039-1679914
复制
发表时间：
2019
影响因子：
2
通讯作者：
Andrew
中科院分区：
文献类型：
--
作者：
Ausbeck,ElizabethB;Jauk,VictoriaC;Boggess,KimA;Saade,GeorgeR;Longo,Sherri;Clark,ErinAS;Esplin,Sean;Cleary,Kirsten;Wapner,Ronald;Letson,Kellett;Owens,Michelle;Abramovici,Adi;Ambalavanan,Namasivayam;Szychowski,JeffM;Andrew
ObjectiveAdding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also reduces wound complications that are identified as noninfectious.Study DesignThis is a secondary analysis of the C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) randomized controlled trial, which enrolled women with singleton pregnancies ≥24 weeks who were undergoing nonelective cesarean. Women were randomized to adjunctive azithromycin or identical placebo up to 1 hour preincision. All wound complications occurring within 6 weeks were adjudicated into infection and noninfectious wound complications (seroma, hematoma, local cellulitis, and other noninfectious wound breakdown). The primary outcome for this analysis is the composite of noninfectious wound complications.ResultsAt a total of 14 sites, 2,013 women were randomized to adjunctive azithromycin (n= 1,019) or placebo (n= 994). Groups were similar at baseline. Although there was a lower rate of noninfectious wound complications in the azithromycin group compared with placebo (2.9 vs. 3.8%), this was not statistically significant (p= 0.22).ConclusionWhile adding azithromycin to usual antibiotic prophylaxis for nonelective cesarean delivery does reduce the risk of postcesarean infections, it did not significantly reduce the risk of postcesarean noninfectious wound complications.
登录
查看更多内容
由杂交瘤抗体鉴定出的人类类风湿因子的常见独特位。
影响因子：
3.6
作者：
Carson,DA;Fong,S
通讯作者：
Fong,S
影响因子：
--
作者：
FOX, RI;ROBINSON, CA;HOWELL, FV
通讯作者：
HOWELL, FV
干燥综合征患者类风湿因子交叉反应独特型的表达。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fox,RI;Chen,P;Carson,DA;Fong,S
通讯作者：
Fong,S
干燥综合征患者的非 IgM 单克隆丙种球蛋白病。
DOI：
10.1016/0002-9343(80)90215-6
发表时间：
1980
期刊：
The American journal of medicine
影响因子：
--
作者：
S. Sugai;S. Konda;Yoshiaki Shirasaki;T. Murayama;T. Nishikawa
通讯作者：
T. Nishikawa
氯喹作为抗风湿剂的对照研究。
影响因子：
--
作者：
A. Cohen;E. Calkins
通讯作者：
E. Calkins