The BRAF(V600E) Mutation Is Not a Risk Factor for More Aggressive Tumor Behavior in Radiogenic and Sporadic Papillary Thyroid Carcinoma at a Young Age.
The BRAF(V600E) Mutation Is Not a Risk Factor for More Aggressive Tumor Behavior in Radiogenic and Sporadic Papillary Thyroid Carcinoma at a Young Age.
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DOI：
10.3390/cancers13236038
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发表时间：
2021-11-30
期刊：
影响因子：
5.2
通讯作者：
Saenko VA
中科院分区：
文献类型：
--
作者：
Zurnadzhy L;Bogdanova T;Rogounovitch TI;Ito M;Tronko M;Yamashita S;Mitsutake N;Chernyshov S;Masiuk S;Saenko VA
对患有放射性和散发性甲状腺乳头状癌（PTC）的年轻乌克兰患者（年龄≤28岁）组的分析显示，BRAFV 600 E的频率随患者年龄增加而增加，在放射性PTC中始终保持较低。在两个病因组中，BRAFV 600 E阳性PTC更常见的是优势乳头状生长模式，肿瘤大小较小，Ki67标记指数较高，肿瘤侵袭性的主要指标频率低于或等于BRAFV 600 E阴性肿瘤。各组间BRAFV 600 E阳性PTC的比较发现几乎没有差异，而BRAFV 600 E阴性肿瘤明显不同，并且在放射性PTC中显示出更高频率的侵袭性肿瘤特征。因此，有证据表明，BRAFV600 E不会在年轻患者中赋予更积极的PTC过程，无论肿瘤病因如何。在融合癌基因驱动的甲状腺乳头状癌（PTC）的儿童和青少年暴露于切尔诺贝利核事故的放射性尘埃的组织学变化已被广泛研究。然而，特征的放射性BRAFV 600 E阳性PTC，其比例随时间而增长，还没有得到很好的描述。我们分析了年龄≤28岁的乌克兰年轻患者的247例放射源性PTC和138例散发性PTC的BRAFV 600 E状态（用VE 1抗体化学测定）与临床病理特征之间的关系。BRAFV 600 E的频率随着患者年龄的增加而增加，在放射性PTC中始终保持较低。在两个病因组中，BRAFV 600 E阳性PTC更常见的是优势乳头状生长模式，肿瘤大小较小，Ki67标记指数较高，肿瘤侵袭性的主要指标频率低于或等于BRAFV 600 E阴性肿瘤。各组间BRAFV 600 E阳性PTC的比较发现几乎不存在差异。与此相反，BRAFV 600 E阴性放射性PTC显示较少的优势乳头状和更频繁的实性生长模式，较低的Ki67标记指数，和较高的侵袭性比BRAFV 600 E阴性散发性肿瘤。因此，BRAFV 600 E与年轻患者中更侵袭性的PTC病程无关，无论病因如何。在BRAFV 600 E阴性肿瘤中观察到放射源性和散发性PTC之间的主要临床病理学差异。
Analysis of the groups of young Ukrainian patients (aged ≤28 years) with radiogenic and sporadic papillary thyroid carcinomas (PTCs) showed that the frequency of BRAFV600E was increasing with patient age, consistently remaining lower in radiogenic PTCs. In both etiopathogenic groups, the BRAFV600E-positive PTCs more frequently had a dominant papillary growth pattern, smaller tumor size, higher Ki67 labeling index, and a frequency of the major indicators of tumor invasiveness that is lower than or equal to that of the BRAFV600E-negative tumors. Comparison of the BRAFV600E-positive PTCs across the groups found a virtual absence of differences, while the BRAFV600E-negative tumors differed markedly and displayed a higher frequency of invasive tumor features in the radiogenic PTCs. Hence, there is evidence that BRAFV600E does not confer a more aggressive course of PTC in young patients regardless of tumor etiology. Histopathological changes in the fusion oncogene-driven papillary thyroid carcinomas (PTCs) from children and adolescents exposed to Chernobyl fallout have been extensively studied. However, characteristics of the radiogenic BRAFV600E-positive PTCs, whose proportion is growing with time, are not well described yet. We analyzed the relationship between the BRAFV600E status (determined immunohistochemically with the VE1 antibody) and the clinicopathological features of 247 radiogenic and 138 sporadic PTCs from young Ukrainian patients aged ≤28 years. The frequency of BRAFV600E was increasing with patient age, consistently remaining lower in radiogenic PTCs. In both etiopathogenic groups, the BRAFV600E-positive PTCs more frequently had a dominant papillary growth pattern, smaller tumor size, higher Ki67 labeling index, and a frequency of the major indicators of tumor invasiveness that is lower than or equal to that of the BRAFV600E-negative tumors. Comparison of the BRAFV600E-positive PTCs across the groups found a virtual absence of differences. In contrast, the BRAFV600E-negative radiogenic PTCs displayed less frequent dominant papillary and more frequent solid growth patterns, lower Ki67 labeling index, and higher invasiveness than the BRAFV600E-negative sporadic tumors. Thus, BRAFV600E is not associated with a more aggressive course of PTC in young patients regardless of etiology. The major clinicopathological differences between the radiogenic and sporadic PTCs are observed among the BRAFV600E-negative tumors.
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影响因子：
9
作者：
Kebebew, Electron;Weng, Julie;Griffin, Ann
通讯作者：
Griffin, Ann
影响因子：
1
作者：
Likhtarov, I.;Thomas, G.;Bouville, A.
通讯作者：
Bouville, A.
影响因子：
2.9
作者：
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通讯作者：
Hassell L
影响因子：
4.7
作者：
Miyauchi, Akira;Kudo, Takumi;Miya, Akihiro
通讯作者：
Miya, Akihiro
影响因子：
5.8
作者：
Li, Carol;Lee, Kathleen C.;Zeiger, Martha A.
通讯作者：
Zeiger, Martha A.