Discriminative and locomotor effects of five synthetic cathinones in rats and mice.
Discriminative and locomotor effects of five synthetic cathinones in rats and mice.
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DOI：
10.1007/s00213-014-3755-3
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发表时间：
2015-04
影响因子：
3.4
通讯作者：
Forster, Michael J.
中科院分区：
文献类型：
--
作者：
Gatch, Michael B.;Rutledge, Margaret A.;Forster, Michael J.
合成卡西酮继续作为甲基苯丙胺或可卡因的“法律的”替代品出售。随着这些边缘法律的化合物受到控制，供应商转向其他不受管制的化合物。这些实验的目的是确定目前在街上滥用的几种暂时受管制的卡西酮化合物是否刺激运动活动，并具有类似于可卡因和/或甲基苯丙胺的区别性刺激作用。在小鼠中测试甲卡西酮、喷替酮、戊酮、3-氟甲卡西酮（3-FMC）和4-甲基乙卡西酮（4-MEC）的运动刺激作用，随后在训练辨别可卡因（10 mg/kg，i. p.）或甲基苯丙胺（lmg/kg，i. p.）来自盐水。甲卡西酮、喷替酮和戊酮产生运动刺激作用，持续长达6小时。此外，戊酮在100 mg/kg时可引起惊厥和致死。4-MEC产生运动刺激作用，持续长达2小时。甲卡西酮，喷替酮，戊酮，3-FMC，和4-MEC每个产生的歧视性刺激效果类似于可卡因和甲基苯丙胺。所有测试的化合物产生类似于可卡因、甲基苯丙胺或两者的区别性刺激作用，这表明这些化合物可能具有与可卡因和/或甲基苯丙胺类似的滥用倾向。戊酮在街上可能更危险，因为它在产生最大兴奋剂样作用的剂量下产生不良反应。
Synthetic cathinones continue to be sold as “legal” alternatives to methamphetamine or cocaine. As these marginally legal compounds become controlled, suppliers move to other, unregulated compounds. The purpose of these experiments was to determine whether several temporarily controlled cathinone compounds, which are currently abused on the street, stimulate motor activity and have discriminative stimulus effects similar to cocaine and/or methamphetamine. Methcathinone, pentedrone, pentylone, 3-fluoromethcathinone (3-FMC), and 4-methylethcathinone (4-MEC) were tested for locomotor stimulant effects in mice and subsequently for substitution in rats trained to discriminate cocaine (10 mg/kg, i.p.) or methamphetamine (1 mg/kg, i.p.) from saline. Methcathinone, pentedrone, and pentylone produced locomotor stimulant effects which lasted up to 6 hours. In addition, pentylone produced convulsions and lethality at 100 mg/kg. 4-MEC produced locomotor stimulant effects which lasted up to 2 hours. Methcathinone, pentedrone, pentylone, 3-FMC, and 4-MEC each produced discriminative stimulus effects similar to those of cocaine and methamphetamine. All of the tested compounds produce discriminative stimulus effects similar to either those of cocaine, methamphetamine or both, which suggests that these compounds are likely to have similar abuse liability to cocaine and/or methamphetamine. Pentylone may be more dangerous on the street, as it produced adverse effects at doses that produced maximal stimulant-like effects.
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DOI：
10.1017/s146114571300059x
发表时间：
2013-10-01
影响因子：
4.8
作者：
Kohut, Stephen J.;Fivel, Peter A.;Mello, Nancy K.
通讯作者：
Mello, Nancy K.
影响因子：
3.6
作者：
GLENNON, RA;YOUSIF, M;KALIX, P
通讯作者：
KALIX, P
影响因子：
3.6
作者：
Bondareva, TS;Young, R;Glennon, RA
通讯作者：
Glennon, RA
影响因子：
3.6
作者：
KAMINSKI, BJ;GRIFFITHS, RR
通讯作者：
GRIFFITHS, RR
影响因子：
2.3
作者：
Meyer, Markus R.;Vollmar, Christian;Maurer, Hans H.
通讯作者：
Maurer, Hans H.