Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinoma.
Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinoma.
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Galectin-4 可作为肝细胞癌早期复发/转移的预后生物标志物。
DOI：
10.1111/cas.12536
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发表时间：
2014-11
期刊：
影响因子：
5.7
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Cai Z;Zeng Y;Xu B;Gao Y;Wang S;Zeng J;Chen L;Huang A;Liu X;Liu J
Galectin-4 是一种多功能凝集素，存在于细胞内和细胞外位点。它可以在结直肠癌发展过程中充当细胞内肿瘤抑制因子并促进细胞外肿瘤转移。然而，半乳糖凝集素4的表达及其对肝细胞癌（HCC）患者的预后价值尚未得到充分研究。在这里，我们报告与非复发/转移性 HCC 患者相比，半乳糖凝集素 4 在早期复发/转移性 HCC 患者中显着下调。 Gelectin-4的低表达与较大的肿瘤尺寸、微血管侵犯、恶性分化、较晚期的TNM分期和不良预后密切相关。过表达galectin-4可以显着减少癌细胞的迁移和侵袭，但在体外敲低galectin-4则可以上调癌细胞的迁移和侵袭。此外，仅乙型肝炎病毒感染即可显着升高血清半乳糖凝集素4水平。结合临床病理特征，较高的半乳糖凝集素4血清学水平与HCC更具侵袭性的特征密切相关。综上所述，galectin-4 表达与 HCC 进展密切相关，可能有作为 HCC 患者预后生物标志物的潜在用途。
Galectin-4 is a multifunctional lectin found at both intracellular and extracellular sites. It could serve as a tumor suppressor intracellularly and promote tumor metastases extracellularly during colorectal cancer development. However, galectin-4 expression and its prognostic value for patients with hepatocellular carcinoma (HCC) have not been well investigated. Here we report that galectin-4 was significantly downregulated in early recurrent/metastatic HCC patients, when compared to non-recurrent/metastatic HCC patients. Low expression of gelectin-4 was well associated with larger tumor size, microvascular invasion, malignant differentiation, more advanced TNM stage, and poor prognosis. Cancer cell migration and invasion could be significantly reduced through overexpression of galectin-4, but upregulated by knocking down of galectin-4 in vitro. Moreover, the serum galectin-4 level could be significantly elevated solely by hepatitis B virus infection. Combined with clinicopathological features, the higher serologic level of galectin-4 was well associated with more aggressive characteristics of HCC. Taken together, galectin-4 expression closely associates with HCC progression and might have potential use as a prognostic biomarker for HCC patients.
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影响因子：
6.4
作者：
Satelli, Arun;Rao, Prema S.;Thirumala, Seshadri;Rao, U. Subrahmanyeswara
通讯作者：
Rao, U. Subrahmanyeswara
影响因子：
3.7
作者：
Paclik D;Danese S;Berndt U;Wiedenmann B;Dignass A;Sturm A
通讯作者：
Sturm A
影响因子：
3
作者：
Huflejt, ME;Leffler, H
通讯作者：
Leffler, H
影响因子：
5.2
作者：
Wu, Ming-Heng;Hong, Tse-Ming;Chen, Yuh-Ling
通讯作者：
Chen, Yuh-Ling
影响因子：
3.3
作者：
Kim, Ha-Jeong;Do, In-Gu;Bae, Duk-Soo
通讯作者：
Bae, Duk-Soo