Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.
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DOI：
10.1371/journal.pone.0254161
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Giuliano AR
中科院分区：
文献类型：
--
作者：
Dickey BL;Sirak B;Martin-Gomez L;Reich RR;Abrahamsen M;Isaacs-Soriano K;Chung CH;Giuliano AR
Rates of oropharyngeal cancer (OPC) associated with alcohol & tobacco use have decreased, while human papillomavirus (HPV) associated OPC has increased among men in the US. Secretory leukocyte protease inhibitor (SLPI), detectable in a variety of secretions, has been implicated in cancers of the head and neck, associated with tumor progression and anti-viral activity. Using the recently verified oral gargle specimen, this study aimed to assess the association of salivary SLPI expression with risk of OPC and response to treatment. A case-control study design compared levels of salivary SLPI among OPC cases to age and tobacco smoking matched healthy controls. Oral HPV DNA and SLPI was quantified from oral gargle specimens. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (CI) for associations of oral SLPI and risk of OPC and treatment outcomes. In crude and adjusted analyses of 96 OPC cases and 97 age- and smoking-matched controls, OPC was not significantly associated with oral gargle SLPI levels. Among cases, oral SLPI was associated with tonsillectomy (p = 0.018) and among controls oral SLPI was associated with HPV in the oral gargle (p = 0.008). Higher concentrations of SLPI was significantly associated with increased odds of incomplete treatment response (T2: OR: 12.39; 95% CI: 1.44–106.72; T3: OR: 9.86; 95% CI: 1.13–85.90) among all cases, but not among P16+ cases. Salivary SLPI was not associated with OPC risk but was associated with higher odds of an incomplete treatment response.
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影响因子：
168.9
作者：
Kreimer, Aimee R.;Campbell, Christine M. Pierce;Lin, Hui-Yi;Fulp, William;Papenfuss, Mary R.;Abrahamsen, Martha;Hildesheim, Allan;Villa, Luisa L.;Salmeron, Jorge J.;Lazcano-Ponce, Eduardo;Giuliano, Anna R.
通讯作者：
Giuliano, Anna R.
影响因子：
7.8
作者：
Martin-Gomez, Laura;Giuliano, Anna R.;Chung, Christine H.
通讯作者：
Chung, Christine H.
影响因子：
9.7
作者：
Quabius, Elgar S.;Goeroegh, Tibor;Hoffmann, Markus
通讯作者：
Hoffmann, Markus
影响因子：
6
作者：
Wen, Jie;Nikitakis, Nikolaos G.;Wahl, Sharon M.
通讯作者：
Wahl, Sharon M.
DOI：
10.1158/1055-9965.epi-08-0151
发表时间：
2008-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Giuliano AR;Lazcano-Ponce E;Villa LL;Flores R;Salmeron J;Lee JH;Papenfuss MR;Abrahamsen M;Jolles E;Nielson CM;Baggio ML;Silva R;Quiterio M
通讯作者：
Quiterio M