Mesenchymal stem cells in fibrotic diseases-the two sides of the same coin.
Mesenchymal stem cells in fibrotic diseases-the two sides of the same coin.
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DOI：
10.1038/s41401-022-00952-0
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发表时间：
2023-03
影响因子：
8.2
通讯作者：
Cao, Hui-ling
中科院分区：
文献类型：
--
作者：
Qin, Lei;Liu, Nian;Bao, Chao-le-meng;Yang, Da-zhi;Ma, Gui-xing;Yi, Wei-hong;Xiao, Guo-zhi;Cao, Hui-ling
纤维化是由细胞外基质（ECM）成分的广泛沉积引起的，ECM成分在损伤修复中起着至关重要的作用。全球约45%的死亡归因于纤维化。不同纤维化疾病的分子病理学不同，并且许多生物活性因子参与致病过程。间充质干细胞（Mesenchymal stem cells，MSCs）是一类多能干细胞，在多种疾病的治疗中具有广阔的应用前景。纤维化发病机制的最新进展表明，驻留MSC可能分化为肌成纤维细胞，导致纤维化的发展。然而，自体或同种异体MSC输注的临床前和临床试验表明，MSC可以通过调节炎症、再生受损组织、重塑ECM和调节植入后应激细胞的死亡来缓解纤维化疾病。开发了各种动物模型来研究不同纤维化组织背后的机制，并测试MSC治疗在这些疾病中的临床前疗效。此外，MSC已在多项临床试验中用于治疗肝硬化和肺纤维化患者，导致令人满意的临床疗效，无严重不良事件。本文从实验室研究和临床试验两个方面综述了宿主间充质干细胞和外源性间充质干细胞在纤维化疾病中的作用，并对间充质干细胞治疗纤维化的机制进行了综述。
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which play a crucial role in injury repair. Fibrosis attributes to ~45% of all deaths worldwide. The molecular pathology of different fibrotic diseases varies, and a number of bioactive factors are involved in the pathogenic process. Mesenchymal stem cells (MSCs) are a type of multipotent stem cells that have promising therapeutic effects in the treatment of different diseases. Current updates of fibrotic pathogenesis reveal that residential MSCs may differentiate into myofibroblasts which lead to the fibrosis development. However, preclinical and clinical trials with autologous or allogeneic MSCs infusion demonstrate that MSCs can relieve the fibrotic diseases by modulating inflammation, regenerating damaged tissues, remodeling the ECMs, and modulating the death of stressed cells after implantation. A variety of animal models were developed to study the mechanisms behind different fibrotic tissues and test the preclinical efficacy of MSC therapy in these diseases. Furthermore, MSCs have been used for treating liver cirrhosis and pulmonary fibrosis patients in several clinical trials, leading to satisfactory clinical efficacy without severe adverse events. This review discusses the two opposite roles of residential MSCs and external MSCs in fibrotic diseases, and summarizes the current perspective of therapeutic mechanism of MSCs in fibrosis, through both laboratory study and clinical trials.
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DOI：
10.1126/science.1223012
发表时间：
2012-08-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Button B;Cai LH;Ehre C;Kesimer M;Hill DB;Sheehan JK;Boucher RC;Rubinstein M
通讯作者：
Rubinstein M
促疾病和抗炎反应在二氧化硅诱导的肺纤维化中的作用。
影响因子：
5.8
作者：
Barbarin V;Nihoul A;Misson P;Arras M;Delos M;Leclercq I;Lison D;Huaux F
通讯作者：
Huaux F
影响因子：
1.8
作者：
Barrachina, L.;Remacha, A. R.;Rodellar, C.
通讯作者：
Rodellar, C.
影响因子：
24.3
作者：
Burgel, Pierre-Regis;Bellis, Gil;Elborn, J. Stuart
通讯作者：
Elborn, J. Stuart
松弛素与螺内酯联用抑制内皮-间质转化对异丙肾上腺素诱导的大鼠心肌纤维化的抗纤维化作用
影响因子：
--
作者：
Cai, Jiejie;Chen, Xiao;Zhou, Hao
通讯作者：
Zhou, Hao