Current state of the art for cardiac arrhythmia gene therapy.
Current state of the art for cardiac arrhythmia gene therapy.
复制标题
心律失常基因治疗的研究现状。
DOI：
10.1016/j.pharmthera.2017.06.005
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发表时间：
2017-08
影响因子：
13.5
通讯作者：
Donahue JK
中科院分区：
文献类型：
--
作者：
Donahue JK
Cardiac arrhythmias are a leading cause of morbidity and mortality. Currently available therapeutic options lack sufficient efficacy and safety. Gene therapy has been proposed for treatment of cardiac arrhythmias. This review will discuss the current state of development for arrhythmia gene therapy. So far, all published studies are short-term, proof-of-concept animal studies. Potential replacement of cardiac pacemakers has been shown for combination gene therapy using the HCN2 gene and either the gene for adenylate cyclase, the skeletal muscle isoform of the sodium channel, or a dominant negative mutant of the potassium channel responsible for resting membrane potential. Atrial fibrillation has been prevented by gene transfer of either a dominant negative mutant of a repolarizing potassium channel, a gap junction, or an siRNA directed against caspase 3. Inherited arrhythmia syndromes have been corrected by replacement of the causative genes. Post-infarct ventricular tachycardia has been reduced by gene therapy with the skeletal muscle sodium channel and connexins and eliminated with the dominant negative mutant of the potassium channel responsible for resting membrane potential. These ideas show considerable promise. Long-term efficacy and safety studies are required to see if they can become viable therapies.
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影响因子：
20.1
作者：
BEUCKELMANN, DJ;NABAUER, M;ERDMANN, E
通讯作者：
ERDMANN, E
影响因子：
37.8
作者：
Igarashi T;Finet JE;Takeuchi A;Fujino Y;Strom M;Greener ID;Rosenbaum DS;Donahue JK
通讯作者：
Donahue JK
影响因子：
5.5
作者：
Coronel, Ruben;Lau, David H.;Rosen, Michael R.
通讯作者：
Rosen, Michael R.
影响因子：
20.1
作者：
Denegri, Marco;Avelino-Cruz, Jose Everardo;Priori, Silvia Giuliana
通讯作者：
Priori, Silvia Giuliana
影响因子：
37.8
作者：
COPLEN, SE;ANTMAN, EM;CHALMERS, TC
通讯作者：
CHALMERS, TC