Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite.
Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite.
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DOI：
10.1107/s2053229622003400
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发表时间：
2022-05-01
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影响因子：
--
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羟基磷灰石是一种复杂的材料，它通常是纳米晶的，并且在生物环境中被取代。用X-射线衍射和X-射线全散射对长程结构和局域结构进行了分析。羟基磷灰石（HA）是一种复杂的材料，当在生物环境中发现时，其通常是纳米晶。这项工作直接比较了从传统的实验室X射线衍射仪收集的数据中获得的结构特征，以及从钻石光源专用的对分布函数（PDF）光束线收集的数据。特别是，PDF分析方法的碳酸化HA的应用进行了评估。使用X射线衍射（XRD）和PDF两者测量20个合成样品。Rietveld精修（实验室XRD数据）和实空间精修（PDF数据）用于分析所有样品。Rietveld和实空间修正的结果是一致的，以评估其应用于晶体和纳米晶羟基磷灰石。显着的关系，观察到真实空间的细化参数和增加碳酸盐取代。了解合成羟基磷灰石的局部顺序可以使包括生物医学和临床设置在内的多个领域受益。
Hydroxyapatite is a complex material, which is often nanocrystalline and substituted within a biological setting. Both long-range and local structures were interrogated with X-ray diffraction and X-ray total scattering. Hydroxyapatite (HA) is a complex material, which is often nanocrystalline when found within a biological setting. This work has directly compared the structural characteristics derived from data collected using a conventional laboratory-based X-ray diffractometer with those collected from a dedicated pair distribution function (PDF) beamline at Diamond Light Source. In particular, the application of PDF analysis methods to carbonated HA is evaluated. 20 synthetic samples were measured using both X-ray diffraction (XRD) and PDFs. Both Rietveld refinement (of laboratory XRD data) and real-space refinement (of PDF data) were used to analyse all samples. The results of Rietveld and real-space refinements were compared to evaluate their application to crystalline and nanocrystalline hydroxyapatite. Significant relationships were observed between real-space refinement parameters and increasing carbonate substitution. Understanding the local order of synthetic hydroxyapatite can benefit several fields, including both biomedical and clinical settings.
影响因子：
4.6
作者：
Arnold EL;Keeble DS;Greenwood C;Rogers KD
通讯作者：
Rogers KD