New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites.
New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites.
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DOI：
10.1038/s41598-020-73200-2
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发表时间：
2020-11-11
影响因子：
4.6
通讯作者：
Rogers KD
中科院分区：
文献类型：
--
作者：
Arnold EL;Keeble DS;Greenwood C;Rogers KD
生物生成和合成的羟基磷灰石是一种令人困惑的材料，即使经过多年的研究，其性能仍不确定。对分布函数分析在20世纪70年代的S和80年代的S中被应用于羟基磷灰石，但这一领域的研究并没有充分利用同步加速器设备的相对最新进展。在这里，同步辐射X射线PDF分析与通常用于表征羟基磷灰石的技术(如广角X射线散射、傅立叶变换红外光谱和热重分析)进行了比较，这些技术适用于一系列具有广泛碳酸盐取代的生物和合成羟基磷灰石。通过主成分分析和PDF的比较，考察了胶原、碳酸盐和有限微晶尺寸对分布函数的贡献。与合成PDF(即r <； 15á)相比，在生物PDF中观察到胶原的显著贡献，这与胶原结构的模拟PDF一致。此外，还观察到具有不同碳酸盐含量的合成羟基磷灰石的PDF的局部结构的变化，特别是在4°、8°和19°附近的特征。建立回归模型，从PDF中的峰值位置预测碳酸盐替代。
Biogenic and synthetic hydroxyapatites are confounding materials whose properties remain uncertain, even after years of study. Pair distribution function (PDF) analysis was applied to hydroxyapatites in the 1970’s and 1980’s, but this area of research has not taken full advantage of the relatively recent advances in synchrotron facilities. Here, synchrotron X-ray PDF analysis is compared to techniques commonly used to characterise hydroxyapatite (such as wide angle X-ray scattering, Fourier-transform infrared spectroscopy and thermogravimetric analysis) for a range of biogenic and synthetic hydroxyapatites with a wide range of carbonate substitution. Contributions to the pair distribution function from collagen, carbonate and finite crystallite size were examined through principal component analysis and comparison of PDFs. Noticeable contributions from collagen were observed in biogenic PDFs when compared to synthetic PDFs (namely r < 15 Å), consistent with simulated PDFs of collagen structures. Additionally, changes in local structure were observed for PDFs of synthetic hydroxyapatites with differing carbonate content, notably in features near 4 Å, 8 Å and 19 Å. Regression models were generated to predict carbonate substitution from peak position within the PDFs.
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影响因子：
2.9
作者：
BRODSKY, B;EIKENBERRY, EF;STERLING, K
通讯作者：
STERLING, K
骨质变化与衰老和疾病有关：评论。
影响因子：
5.2
作者：
Boskey AL;Imbert L
通讯作者：
Imbert L
影响因子：
2.5
作者：
Basham M;Filik J;Wharmby MT;Chang PC;El Kassaby B;Gerring M;Aishima J;Levik K;Pulford BC;Sikharulidze I;Sneddon D;Webber M;Dhesi SS;Maccherozzi F;Svensson O;Brockhauser S;Náray G;Ashton AW
通讯作者：
Ashton AW
影响因子：
6.2
作者：
Gourion-Arsiquaud, Samuel;Faibish, Dan;Boskey, Adele L.
通讯作者：
Boskey, Adele L.
DOI：
10.1016/0141-8130(91)90058-3
发表时间：
1991-04-01
影响因子：
8.2
作者：
BIGI, A;RIPAMONTI, A;KOCH, MHJ
通讯作者：
KOCH, MHJ