Dendritic cell-based autologous tumor vaccines for head and neck squamous cell carcinoma.
Dendritic cell-based autologous tumor vaccines for head and neck squamous cell carcinoma.
复制标题
DOI：
10.1002/hed.24025
复制
发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Johnson JT
中科院分区：
文献类型：
--
作者：
Whiteside TL;Ferris RL;Szczepanski M;Tublin M;Kiss J;Johnson R;Johnson JT
将凋亡肿瘤细胞（ATC）和树突状细胞（DC）的自体疫苗给予III/IV期HNSCC患者以研究安全性和可行性。自体DC由单核细胞产生，负载ATC并经结内递送。迟发型超敏反应（DTH）和免疫学终点在接种前/后进行测量。需要临床随访。从30例患者中获得的肿瘤产生2 × 106 - 2 × 108肿瘤细胞。只有19/30（63%）是无菌的。10/30例患者（33%）具有≥ 1 × 107个疫苗生产所需的无菌肿瘤细胞。8/10例有阳性回忆DTH。5/10例进行白细胞分离以产生DC。4/5接种疫苗。在3/4例患者中检测到ATC反应性T细胞。所有4例均存活> 5年。该试验未能招募预计的12名患者并终止。该疫苗具有安全性和免疫原性，但仅适用于疫苗前DTH阳性且无菌肿瘤细胞≥ 1 × 107的HNSCC患者。所有接种疫苗的患者都是长期无病存活者。[单词，150]
An autologous vaccine of apoptotic tumor cells (ATC) & dendritic cells (DC) was administered to stage III/IV HNSCC patients to study safety and feasibility. Autologous DC were generated from monocytes, loaded with ATC and delivered intranodally. Delayed-type hypersensitivity (DTH) and immunological endpoints were measured pre/post vaccination. Clinical follow-up was required. Tumors obtained from 30 patients yielded 2×106 – 2×108 tumor cells. Only 19/30 (63%) were sterile. 10/30 patients (33%) had ≥1×107 sterile tumor cells required for vaccine production. 8/10 had positive recall DTH. 5/10 were leukapheresed to generate DC. 4/5 were vaccinated. ATC-reactive T cells were detected in 3/4 patients. All 4 survived > 5 years. The trial failed to enroll the projected 12 patients and was terminated. This vaccine was safe and immunogenic but feasible only in HNSCC patients with positive pre-vaccine DTH and ≥1×107 sterile tumor cells. All vaccinated patients were long-term disease-free survivors. [Words, 150]
登录
查看更多内容
影响因子：
7.4
作者：
Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
通讯作者：
Fox BA
影响因子：
11.2
作者：
Karcher, J;Dyckhoff, G;Herold-Mende, C
通讯作者：
Herold-Mende, C
影响因子：
4
作者：
Berzofsky JA;Terabe M;Wood LV
通讯作者：
Wood LV
DOI：
10.1002/hed.21975
发表时间：
2013-02
影响因子：
2.9
作者：
Lucs, Alexandra V.;Saltman, Benjamin;Chung, Christine H.;Steinberg, Bettie M.;Schwartz, David L.
通讯作者：
Schwartz, David L.
影响因子：
4.4
作者：
Lopez-Albaitero, Andres;Nayak, Jayakar V.;Ferris, Robert L.
通讯作者：
Ferris, Robert L.