A randomized trial of nicotine nasal spray in adolescent smokers.
A randomized trial of nicotine nasal spray in adolescent smokers.
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DOI：
10.1542/peds.2008-0501
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发表时间：
2008-09
期刊：
影响因子：
8
通讯作者：
Moscicki AB
中科院分区：
文献类型：
--
作者：
Rubinstein ML;Benowitz NL;Auerback GM;Moscicki AB
Nicotine nasal spray has been one of the most successful forms of nicotine replacement therapy in adult populations. The nasal sprayer has not been studied in adolescent smokers. The objective of this pilot study is to determine the feasibility and utility of using nicotine nasal spray (NNS) in adolescent smokers who want to quit smoking. Forty adolescent smokers between 15 and 18 years-old, who smoked 5 or more cigarettes daily for at least 6 months were recruited from several San Francisco Bay area schools from 2005–2007. Using a randomized, open-label, 12-week trial, adolescent smokers were assigned to receive either weekly counseling alone (control) for 8 weeks or 8 weeks of counseling along with 6 weeks of NNS. Self-reported smoking abstinence verified by both expired-air carbon monoxide and salivary cotinine. There was no difference in cessation rates, the numbers of cigarettes smoked per day or cotinine levels at 12 weeks (p=.16, p=.22, and p=.16 respectively). Fifty seven percent of participants stopped using their spray after only one week. The most commonly reported side effect was nasal irritation and burning (34.8%) followed by complaints about the taste and smell (13%). The unpleasant side effects, poor adherence, and consequent lack of efficacy observed in our pilot study do not support the use of nicotine nasal spray as an adjunct to counseling for adolescent smokers wishing to quit.
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DOI：
10.1177/105984050101700206
发表时间：
2001-04-01
期刊：
The Journal of school nursing : the official publication of the National Association of School Nurses
影响因子：
--
作者：
Dino, G A;Horn, K A;Massey, C J
通讯作者：
Massey, C J
影响因子：
4.4
作者：
Horn, K;Fernandes, A;Kalsekar, I
通讯作者：
Kalsekar, I
影响因子：
5.1
作者：
Sussman, S;Dent, CW;Flay, BR
通讯作者：
Flay, BR
影响因子：
--
作者：
Blondal, T;Gudmundsson, LJ;Westin, A
通讯作者：
Westin, A
影响因子：
120.7
作者：
HURT, RD;DALE, LC;LUNDBERG, TG
通讯作者：
LUNDBERG, TG