Advances in Chronic Obstructive Pulmonary Disease.

Advances in Chronic Obstructive Pulmonary Disease.
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慢性阻塞性肺疾病研究进展。

DOI:
10.1146/annurev-med-080919-112707
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发表时间:
2021-01-27
影响因子:
10.5
通讯作者:
Han MK
Han MK
中科院分区:
医学1区
文献类型:
--
作者:
Ferrera MC;Labaki WW;Han MK

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慢性阻塞性肺疾病(COPD)是一种常见的呼吸系统疾病,发病率和死亡率都很高。尽管它很流行,但COPD的诊断不足,许多患者直到疾病临床进展才得到诊断。最近的基础科学和临床研究集中在COPD的早期生理和病理变化上,希望能提高诊断水平,为疾病改善治疗提供靶点,并确定最有可能从早期干预中受益的患者。在过去的20年中,随着新的口服和吸入药物以及新的外科和支气管镜手术的引入,COPD的可用治疗方法大大增加。本文综述了近年来我们对疾病发病机制和治疗模式的认识的一些进展。
Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder with significant morbidity and mortality. Despite its prevalence, COPD is underdiagnosed, and many patients do not receive a diagnosis until the disease is clinically advanced. Recent basic science and clinical research have focused on the early physiologic and pathobiologic changes in COPD with the hopes of improving diagnosis, providing targets for disease-modifying therapy, and identifying patients most likely to benefit from early intervention. Available treatments for COPD have grown substantially in the past 20 years with the introduction of new oral and inhaled medications as well as novel surgical and bronchoscopic procedures. This article summarizes some of the recent advances in our understanding of disease pathogenesis and treatment paradigms.
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