Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort.
Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort.
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DOI：
10.1016/j.joca.2010.02.002
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发表时间：
2010-06
影响因子：
7
通讯作者：
Lewis, C. E.
中科院分区：
文献类型：
--
作者：
Segal, N. A.;Glass, N. A.;Torner, J.;Yang, M.;Felson, D. T.;Sharma, L.;Nevitt, M.;Lewis, C. E.
在纵向研究中，有股四头肌无力的报道，但没有进行性膝骨性关节炎(OA)的报道。这项研究考察了30个月来股四头肌力量与膝关节间隙变窄(JSN)恶化的关系。以OARSI JSN评分和3为基线的50-79岁成年人的纵向观察性研究。基线测量包括双侧负重固定屈曲X线片、等速同心股四头肌和腿筋力量、身高和体重以及体力活动。肌腱：股四头肌(H：Q)的力量比也被评估。恶化被定义为在30个月的X线片或全膝关节置换术中胫股和/或髌股间室的JSN评分增加。基于膝关节的分析使用按性别分层的通用估计方程来评估力量和膝关节JSN之间的关系，同时控制受试者内膝关节之间的协方差以及年龄、BMI、膝关节损伤和/或手术史、体力活动水平和排列。3856个膝关节(男性1602个，女性2254个)在基线时JSN评分为3分，没有丢失的随访数据纳入其中。男性平均年龄为61.6±8.1岁，女性为62.2±7.7岁。股四头肌力量最低三分位数的女性患全膝关节关节突触后(OR=1.66，95%CI=1.26，2.19)和胫股关节突触后(OR=1.69，95%CI=1.26，2.28)的风险增加。然而，在男性的力量和JSN之间没有发现关联，在男性和女性的H：Q<；0.6和JSN之间没有发现关联。在女性中，但在男性中，股四头肌无力与胫股和全膝关节突关节滑脱风险增加相关。
Quadriceps weakness has been reported with incident but not progressive knee osteoarthritis (OA) in longitudinal studies. This study examined the relationship between quadriceps strength and worsening of knee joint space narrowing (JSN) over 30 months. Longitudinal, observational study of adults aged 50-79 years with OARSI JSN score <3 at baseline. Baseline measures included bilateral weight-bearing fixed flexion radiographs, isokinetic concentric quadriceps and hamstring strength, height and weight, and physical activity. Hamstring:quadriceps (H:Q) strength ratios also were evaluated. Worsening was defined as an increase in JSN score in the tibiofemoral and/or patellofemoral compartments on 30-month radiographs or total knee replacement. Knee-based analyses used generalized estimating equations, stratified by sex, to assess relationships between strength and knee JSN while controlling for covariance between knees within subjects as well as age, BMI, history of knee injury and/or surgery, physical activity level and alignment. 3856 knees (1602 male and 2254 female) with JSN score <3 at baseline and no missing follow-up data were included. Mean±SD age was 61.6±8.1 in men and 62.2±7.7 in women. Women in the lowest tertile of quadriceps strength had an increased risk of whole knee JSN (OR=1.66, 95% CI=1.26, 2.19) and tibiofemoral JSN (OR=1.69, 95% CI=1.26, 2.28). However, no associations were found between strength and JSN in men or H:Q<0.6 and JSN in men or women. In women but not in men, quadriceps weakness was associated with increased risk for tibiofemoral and whole knee JSN.
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影响因子：
--
作者：
Cicuttini, FM;Teichtahl, AJ;Ebeling, PR
通讯作者：
Ebeling, PR
影响因子：
3
作者：
Jaric, S;Radosavljevic-Jaric, S;Johansson, H
通讯作者：
Johansson, H
DOI：
10.1111/j.1748-1716.1995.tb09927.x
发表时间：
1995-08-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
AAGAARD, P;SIMONSEN, EB;KLAUSEN, K
通讯作者：
KLAUSEN, K
影响因子：
27.4
作者：
Hall, MC;Mockett, SP;Doherty, M
通讯作者：
Doherty, M
影响因子：
--
作者：
Baker, KR;Xu, L;Felson, D
通讯作者：
Felson, D