Exercise alters resting-state functional connectivity of motor circuits in parkinsonian rats.
Exercise alters resting-state functional connectivity of motor circuits in parkinsonian rats.
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DOI：
10.1016/j.neurobiolaging.2014.08.016
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发表时间：
2015-01
影响因子：
4.2
通讯作者：
Holschneider DP
中科院分区：
文献类型：
--
作者：
Wang Z;Guo Y;Myers KG;Heintz R;Peng YH;Maarek JM;Holschneider DP
很少有研究考察长期有氧运动后功能连接的变化。我们研究了为期4周的强迫跑轮运动对大鼠双侧背侧纹状体6-羟基多巴胺损伤后运动回路静息态功能连接（rsFC）的影响。我们的研究结果表明，在大鼠中损伤诱导的rsFC变化与帕金森病受试者中报告的rsFC变化（包括背外侧纹状体断开）之间存在实质性相似性。在损伤大鼠中进行运动导致：（a）许多损伤诱导的rsFC改变正常化，包括背外侧纹状体重新融入运动网络;（B）腹外侧纹状体作为新的广泛连接的网络枢纽出现;（c）运动皮层、运动丘脑、基底神经节和小脑之间的rsFC增加。我们的研究结果首次表明，长期运动训练部分逆转了损伤诱导的运动回路rsFC的改变，此外还增强了帕金森病大鼠特定运动通路的功能连接，这可能是这些大鼠运动功能恢复的基础。
Few studies have examined changes in functional connectivity after long-term aerobic exercise. We examined the effects of 4 weeks of forced running wheel exercise on the resting-state functional connectivity (rsFC) of motor circuits of rats subjected to bilateral 6-hydroxydopamine lesion of the dorsal striatum. Our results showed substantial similarity between lesion-induced changes in rsFC in the rats and alterations in rsFC reported in Parkinson’s disease subjects, including disconnection of the dorsolateral striatum. Exercise in lesioned rats resulted in: (a) normalization of many of the lesion-induced alterations in rsFC, including reintegration of the dorsolateral striatum into the motor network; (b) emergence of the ventrolateral striatum as a new broadly connected network hub; (c) increased rsFC among the motor cortex, motor thalamus, basal ganglia, and cerebellum. Our results showed for the first time that long-term exercise training partially reversed lesion-induced alterations in rsFC of the motor circuits, and in addition enhanced functional connectivity in specific motor pathways in the Parkinsonian rats, which could underlie recovery in motor functions observed in these rats.
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影响因子：
3.7
作者：
Göttlich M;Münte TF;Heldmann M;Kasten M;Hagenah J;Krämer UM
通讯作者：
Krämer UM
影响因子：
0.5
作者：
KAMADA, T;KAWAI, S
通讯作者：
KAWAI, S
DOI：
10.1016/j.apmr.2008.01.013
发表时间：
2008-07-01
影响因子：
4.3
作者：
Fisher, Beth E.;Wu, Allan D.;Petzinger, Giselle
通讯作者：
Petzinger, Giselle
影响因子：
--
作者：
Hilker, R;Schweitzer, K;Heiss, WD
通讯作者：
Heiss, WD
影响因子：
2.9
作者：
DAHLGREN, N;LINDVALL, O;STENEVI, U
通讯作者：
STENEVI, U