The Contribution of Pharmacogenetic Drug Interactions to 90-Day Hospital Readmissions: Preliminary Results from a Real-World Healthcare System.
The Contribution of Pharmacogenetic Drug Interactions to 90-Day Hospital Readmissions: Preliminary Results from a Real-World Healthcare System.
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药物遗传学药物相互作用对90天再入院的贡献：来自现实世界医疗保健系统的初步结果。
DOI：
10.3390/jpm11121242
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发表时间：
2021-11-23
影响因子：
--
通讯作者：
Dunnenberger HM
中科院分区：
文献类型：
--
作者：
David SP;Singh L;Pruitt J;Hensing A;Hulick P;Meltzer DO;O'Donnell PH;Dunnenberger HM
临床药物遗传学实施联盟（CPIC）的指南存在于出院前常用的许多药物中，但关于基因-x-药物相互作用对再入院的贡献的数据有限。本研究评估了2010年至2020年期间接受14基因药物遗传学测序的研究人群（N = 10，104）中入院后30天内开出的CPIC药物处方与90天再次入院之间的关系。面板。在入院后30天内处方的药物中存在至少一种药物遗传学指标被认为是基因-x-药物相互作用。多变量逻辑回归分析了一个或多个基因-x-药物相互作用与90天再入院之间的关系。2211/2354（93.9%）例住院患者至少接受了一种CPIC药物治疗。单变量分析表明，存在至少一种确定的基因-x-药物相互作用使90天再入院的风险增加40%以上（OR = 1.42，95%置信区间（CI）1.09-1.84）（p = 0.01）。调整年龄、种族、性别、就业状况、体重指数和医疗状况的多变量模型略微减弱了该效应（OR = 1.32，95% CI 1.02-1.73）（p = 0.04）。我们的研究结果表明，存在一种或多种CPIC基因-X-药物相互作用会增加90天再入院的风险，即使在调整人口统计学和临床风险因素后也是如此。
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines exist for many medications commonly prescribed prior to hospital discharge, yet there are limited data regarding the contribution of gene-x-drug interactions to hospital readmissions. The present study evaluated the relationship between prescription of CPIC medications prescribed within 30 days of hospital admission and 90-day hospital readmission from 2010 to 2020 in a study population (N = 10,104) who underwent sequencing with a 14-gene pharmacogenetic panel. The presence of at least one pharmacogenetic indicator for a medication prescribed within 30 days of hospital admission was considered a gene-x-drug interaction. Multivariable logistic regression analyzed the association between one or more gene-x-drug interactions with 90-day readmission. There were 2211/2354 (93.9%) admitted patients who were prescribed at least one CPIC medication. Univariate analyses indicated that the presence of at least one identified gene-x-drug interaction increased the risk of 90-day readmission by more than 40% (OR = 1.42, 95% confidence interval (CI) 1.09–1.84) (p = 0.01). A multivariable model adjusting for age, race, sex, employment status, body mass index, and medical conditions slightly attenuated the effect (OR = 1.32, 95% CI 1.02–1.73) (p = 0.04). Our results suggest that the presence of one or more CPIC gene-x-drug interactions increases the risk of 90-day hospital readmission, even after adjustment for demographic and clinical risk factors.
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影响因子：
3.7
作者：
Elliott LS;Henderson JC;Neradilek MB;Moyer NA;Ashcraft KC;Thirumaran RK
通讯作者：
Thirumaran RK
Flype：用于启用个性化医学的软件。
DOI：
10.1002/ajmg.c.31867
发表时间：
2021-03
期刊：
American journal of medical genetics. Part C, Seminars in medical genetics
影响因子：
--
作者：
Helseth DL Jr;Gulukota K;Miller N;Yang M;Werth T;Sabatini LM;Bouma M;Dunnenberger HM;Wake DT;Hulick PJ;Kaul KL;Khandekar JD
通讯作者：
Khandekar JD
影响因子：
1.9
作者：
Takahashi PY;Ryu E;Bielinski SJ;Hathcock M;Jenkins GD;Cerhan JR;Olson JE
通讯作者：
Olson JE
影响因子：
2.4
作者：
Brixner, D.;Biltaji, E.;Biskupiak, J.
通讯作者：
Biskupiak, J.
影响因子：
158.5
作者：
Zuckerman, Rachael B.;Sheingold, Steven H.;Epstein, Arnold M.
通讯作者：
Epstein, Arnold M.