Test-retest reliability and predictive utility of a macroscale principal functional connectivity gradient.
Test-retest reliability and predictive utility of a macroscale principal functional connectivity gradient.
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DOI：
10.1002/hbm.26517
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发表时间：
2023-12-15
影响因子：
4.8
通讯作者：
Hariri, Ahmad R.
中科院分区：
文献类型：
--
作者：
Knodt, Annchen R.;Elliott, Maxwell L.;Whitman, Ethan T.;Winn, Alex;Addae, Angela;Ireland, David;Poulton, Richie;Ramrakha, Sandhya;Caspi, Avshalom;Moffitt, Terrie E.;Hariri, Ahmad R.
关键词：
绘制大脑功能的个体差异受到可靠性差和可解释性有限的阻碍。利用全脑功能连接（FC）的模式为这一努力提供了一些希望。特别是，一个宏观尺度的主要FC梯度，概括了一个层次组织跨越分子，细胞，电路水平的特点沿着感觉到联想皮层轴已成为一个吝啬和可解释的措施，个体差异的行为。然而，该FC梯度的测量可靠性尚未得到充分评价。在这里，我们使用来自年轻成人人类连接组项目（HCP ‐ YA）和达尼丁研究的重测数据评估了全球和区域主要FC梯度测量的可靠性。分析显示，主要FC梯度测量的可靠性（1）始终高于传统边缘FC测量的可靠性，（2）与静息状态FC相比，来自一般FC（GFC）的FC测量的可靠性更高，（3）扫描长度更长时更高。我们还检查了这些主要FC梯度测量在预测两个数据集以及HCP老化数据集的认知和老化方面的相对效用。这些分析显示，在所有三个数据集中，局部FC梯度测量值和全局梯度范围与老化显著相关，在HCP ‐ YA和达尼丁研究数据集中与认知中度相关，分别反映了皮质层级的收缩和扩张。总的来说，这些结果表明，主要FC梯度的测量，特别是使用GFC导出的测量，有效地捕获了人类大脑的可靠特征，这些特征受到可解释的和具有生物学意义的个体差异的影响，在搜索大脑行为关联时，比传统的边缘FC测量提供了一些优势。我们证明，概括人类皮层基本生物学特征的宏观层次功能连接梯度比传统的边缘测量具有更高的重测信度，特别是当来自静息状态和基于任务的数据时。此外，梯度测量捕获老化和认知的个体差异。
Mapping individual differences in brain function has been hampered by poor reliability as well as limited interpretability. Leveraging patterns of brain‐wide functional connectivity (FC) offers some promise in this endeavor. In particular, a macroscale principal FC gradient that recapitulates a hierarchical organization spanning molecular, cellular, and circuit level features along a sensory‐to‐association cortical axis has emerged as both a parsimonious and interpretable measure of individual differences in behavior. However, the measurement reliabilities of this FC gradient have not been fully evaluated. Here, we assess the reliabilities of both global and regional principal FC gradient measures using test–retest data from the young adult Human Connectome Project (HCP‐YA) and the Dunedin Study. Analyses revealed that the reliabilities of principal FC gradient measures were (1) consistently higher than those for traditional edge‐wise FC measures, (2) higher for FC measures derived from general FC (GFC) in comparison with resting‐state FC, and (3) higher for longer scan lengths. We additionally examined the relative utility of these principal FC gradient measures in predicting cognition and aging in both datasets as well as the HCP‐aging dataset. These analyses revealed that regional FC gradient measures and global gradient range were significantly associated with aging in all three datasets, and moderately associated with cognition in the HCP‐YA and Dunedin Study datasets, reflecting contractions and expansions of the cortical hierarchy, respectively. Collectively, these results demonstrate that measures of the principal FC gradient, especially derived using GFC, effectively capture a reliable feature of the human brain subject to interpretable and biologically meaningful individual variation, offering some advantages over traditional edge‐wise FC measures in the search for brain–behavior associations. We demonstrate that a macroscale hierarchical functional connectivity gradient that recapitulates fundamental biological features of the human cortex has higher test–retest reliability than traditional edge‐wise measures, especially when derived from combined resting‐state and task‐based data. Further, gradient measures capture individual differences in aging and cognition.
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影响因子：
5.7
作者：
Brown, Jesse A.;Lee, Alex J.;Pasquini, Lorenzo;Seeley, William W.
通讯作者：
Seeley, William W.
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
2.5
作者：
Coifman, Ronald R.;Hirn, Matthew J.
通讯作者：
Hirn, Matthew J.
影响因子：
4.8
作者：
Chen G;Taylor PA;Haller SP;Kircanski K;Stoddard J;Pine DS;Leibenluft E;Brotman MA;Cox RW
通讯作者：
Cox RW
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y