Effects of tDCS on Depression and Comorbid Generalized Anxiety Disorder: A Brain Function Imaging Case Report.
Effects of tDCS on Depression and Comorbid Generalized Anxiety Disorder: A Brain Function Imaging Case Report.
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经颅直流电刺激 (tDCS) 对抑郁症和共病广泛性焦虑症的影响：脑功能成像病例报告
DOI：
10.3389/fneur.2022.879339
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发表时间：
2022
影响因子：
3.4
通讯作者：
Shan, Chunlei
中科院分区：
文献类型：
--
作者：
Wu, Yuwei;Tang, Lin;Shi, Xiaolong;Zhou, Zhiqing;Li, Yuanli;Shan, Chunlei
关键词：
经颅直流电刺激（tDCS）是一种非侵入性脑刺激技术，已被证明对神经精神疾病有效。广泛性焦虑症（GAD）和抑郁症是常见的精神疾病，通常是共病的，这意味着它们同时发生。目前的证据支持tDCS治疗广泛性焦虑症的价值。本报告的目的是探讨tDCS对广泛性焦虑症合并抑郁症患者临床症状和脑功能的影响。我们的研究对象是一名半职业运动员，被诊断患有广泛性焦虑症和抑郁症。症状包括心悸、出汗、持续紧张和焦虑。我们设计了B-A-B实验方案，并采用Beck焦虑指数（BAI）、Beck抑郁指数（BDI）和匹兹堡睡眠质量指数（PSQI）作为评估工具。治疗包括2个系列，每个15天，间隔3周的洗脱期。我们收集了两个系列治疗前后的功能近红外光谱（fNIRS）数据，以及两个系列首次治疗后的fNIRS数据。此外，我们收集了第二组前后的功能磁共振成像数据。经过第一个系列，三个问卷（BAI， BDI和PSQI）得分明显下降，呈现改善趋势。tDCS治疗后，双侧额叶部分通道的功能连接明显减少。第二次系列治疗前的fNIRS结果显示，在洗脱期后，前额叶连通性恢复到第一次干预前的状态。第二系列治疗后的fNIRS结果显示，抑郁和焦虑症状有所缓解。fNIRS结果显示，前额叶连通性再次下降。在治疗广泛性焦虑症和抑郁症的合并症中，tDCS可以缓解症状，改善睡眠质量和社会行为。脑成像被广泛用于观察tDCS的功能变化，如fMRI和fNIRS。该研究还表明，近红外光谱是一种安全、简单、有效的评估大脑活动的方法。
Transcranial direct current stimulation (tDCS) is a type of non-invasive brain stimulation technique that has proven effective for neuropsychiatric disorders. Generalized anxiety disorder (GAD) and depression are common psychiatric disorders that often are comorbid, meaning they occur simultaneously. Current evidence supports the value of tDCS for GAD. The objectives of this report is to explore the effect of tDCS on clinical symptoms and cerebral function in a patient with comorbid GAD and depression. Our subject was a semiprofessional athlete diagnosed with comorbid GAD and depression. Symptoms included palpitations, sweating, continuous tension, and anxiety. We designed a B-A-B experimental protocol and used the Beck Anxiety Index (BAI), Beck Depression Index (BDI), and Pittsburgh Sleep Quality Index (PSQI) as assessment tools. Treatment consisted of 2 series of 15 days each, separated by a 3-week washout period. We collected functional near-infrared spectroscopy (fNIRS) data before and after both series, as well as fNIRS data immediately after the first treatment in both series. In addition, we collected functional magnetic resonance imaging data before and after the second series. After the first series, the scores of the three questionnaires (BAI, BDI and PSQI) decreased significantly, which showed the trend of improvement. The functional connection of bilateral prefrontal partial channels decreased significantly immediately after tDCS treatment. The results of the fNIRS before the second-series treatment showed that prefrontal connectivity returned to the state before the first intervention after the washout period. The results of the fNIRS after the second series treatment showed that the symptoms of depression and anxiety alleviated. The results of the fNIRS showed that the prefrontal connectivity decreased again. In the treatment of comorbid GAD and depression, tDCS can alleviate symptoms and improve sleep quality and social behavior. Brain imaging is widely used to observe functional changes by tDCS such as fMRI and fNIRS. The study also showed that fNIRS can be a safe, simple, and efficient method to assess brain activity.
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