State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability.
State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability.
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DOI：
10.3389/fnsys.2018.00036
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发表时间：
2018
影响因子：
3
通讯作者：
Wisor JP
中科院分区：
文献类型：
--
作者：
Grønli J;Schmidt MA;Wisor JP
尽管睡眠时间和持续时间正常，但Egr 3缺陷（Egr 3 −/−）小鼠表现出唤醒减少的脑电图（EEG）特征，包括清醒期间慢波（1-4 Hz）活动升高。在这里，我们表明，这些小鼠表现出状态依赖的EEG不稳定性。在清醒和快速眼动睡眠期间，在Egr 3 −/−小鼠中发现了EEG功率的间歇性浪涌，与野生型（Egr 3 +/+）小鼠相比，在β（15-35 Hz）范围内最为突出。这种浪涌不符合睡眠开始，因为浪涌与肌电音调的停止无关。视觉诱发反应（VEP）的感觉信息的皮层处理被发现作为警觉状态的函数而变化，在慢波睡眠（SWS）期间比清醒和快速眼动睡眠期间具有更高的幅度。在Egr 3 −/−小鼠和Egr 3 +/+小鼠中，安静觉醒期间的VEP反应明显大于主动觉醒。在β范围内的EEG同步，以前与随着时间的推移睡眠需求的积累有关，预测VEP幅度。Egr 3 −/−小鼠不仅表现出升高的β活性，而且在安静的清醒状态下，这种升高的β活性与类似于SWS动物的诱发反应升高相一致。这些数据证实：（a）VEP作为警觉状态的函数而变化，（B）EEG中的β活动是视觉信息处理的状态依赖性调制的预测因子。Egr 3 −/−小鼠的表型表明Egr 3是这些现象的遗传调节因子。
Despite normal sleep timing and duration, Egr3-deficient (Egr3−/−) mice exhibit electroencephalographic (EEG) characteristics of reduced arousal, including elevated slow wave (1–4 Hz) activity during wakefulness. Here we show that these mice exhibit state-dependent instability in the EEG. Intermittent surges in EEG power were found in Egr3−/− mice during wakefulness and rapid eye movement sleep, most prominently in the beta (15–35 Hz) range compared to wild type (Egr3+/+) mice. Such surges did not coincide with sleep onset, as the surges were not associated with cessation of electromyographic tone. Cortical processing of sensory information by visual evoked responses (VEP) were found to vary as a function of vigilance state, being of higher magnitude during slow wave sleep (SWS) than wakefulness and rapid eye movement sleep. VEP responses were significantly larger during quiet wakefulness than active wakefulness, in both Egr3−/− mice and Egr3+/+ mice. EEG synchronization in the beta range, previously linked to the accumulation of sleep need over time, predicted VEP magnitude. Egr3−/− mice not only displayed elevated beta activity, but in quiet wake, this elevated beta activity coincides with an elevated evoked response similar to that of animals in SWS. These data confirm that (a) VEPs vary as a function of vigilance state, and (b) beta activity in the EEG is a predictor of state-dependent modulation of visual information processing. The phenotype of Egr3−/− mice indicates that Egr3 is a genetic regulator of these phenomena.
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影响因子：
4.5
作者：
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发表时间：
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作者：
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