Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women.
Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women.
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DOI：
10.1007/s00213-021-06032-1
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发表时间：
2022-05
影响因子：
3.4
通讯作者：
de Wit H
中科院分区：
文献类型：
--
作者：
Wardle MC;Pabon E;Webber HE;de Wit H
The use of cannabis has been clinically associated with decreased motivation to engage in normally rewarding activities. However, evidence from previous controlled studies is mixed. In this study, we examined the effects of acute delta-9-tetrahydrocannabinol (THC) versus placebo on a task measuring willingness to exert effort for rewards. This is a secondary analysis of a larger study examining interactions between ovarian hormones and THC. In this within-subjects study, oral THC and placebo were administered under double-blind conditions in counterbalanced order to healthy young adult (M age = 24 years) women with previous cannabis experience who were not regular users. Forty subjects completed three 4-h sessions with PL, 7.5 and 15 mg THC, while an additional 18 completed only PL and 15 mg THC sessions (design abridged due to pandemic). At each session, they completed a task consisting of making repeated choices between a hard and an easy task, which were worth varying amounts of money at varying probabilities. THC dose-dependently decreased hard task choices (drug effect, b = − 0.79, SE = 0.29, z = − 2.67, p < 0.01), especially at moderate to high expected values of reward (drug × probability × amount interaction, b = 0.77, SE = 0.38, z = 1.99, p = 0.04). THC also slowed task performance (drug effect, b = 0.01, SE = 0.005, t(5.24) = 2.11, p = 0.04), but the effect of THC on choice was still significant after controlling for this psychomotor slowing. These findings support the idea that cannabis acutely reduces motivation to earn non-drug rewards. Still to be determined are the neurochemical mechanisms underlying this effect.
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DOI：
10.1111/add.13912
发表时间：
2017-12
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Leventhal AM;Cho J;Stone MD;Barrington-Trimis JL;Chou CP;Sussman SY;Riggs NR;Unger JB;Audrain-McGovern J;Strong DR
通讯作者：
Strong DR
影响因子：
6
作者：
Freeman, Tom P.;Lorenzetti, Valentina
通讯作者：
Lorenzetti, Valentina
影响因子：
3.3
作者：
Barnwell, Sara Smucker;Earleywine, Mitch;Wilcox, Rand
通讯作者：
Wilcox, Rand
影响因子：
2.7
作者：
FOLTIN, RW;FISCHMAN, MW;KELLY, TH
通讯作者：
KELLY, TH
影响因子：
2
作者：
Petrucci, Aria S.;LaFrance, Emily M.;Cuttler, Carrie
通讯作者：
Cuttler, Carrie