Integration of intercellular signaling through the Hippo pathway.
Integration of intercellular signaling through the Hippo pathway.
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DOI：
10.1016/j.semcdb.2012.04.006
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发表时间：
2012-09
影响因子：
7.3
通讯作者：
Irvine, Kenneth D.
中科院分区：
文献类型：
--
作者：
Irvine, Kenneth D.
后生动物细胞暴露在多种信号中，它们将这些信号整合在一起，以确定适当的发育或生理反应。虽然河马途径是最近才发现的，我们对河马信号转导的了解还很不完整，但已经发现了河马和其他信号通路之间的丰富的相互联系。河马信号对于生长控制特别重要，我描述了河马和其他途径的整合如何有助于器官生长的调节。综述了河马信号与其他信号转导途径之间的分子联系。描述了不同类型的信号整合机制，并讨论了如何使用通路之间的复杂互连来指导发育和生理生长反应的例子。河马信号的特点似乎使它特别适合于信号整合，包括它对细胞-细胞接触的响应，以及它的转录输出由转录共激活蛋白调节，这些共激活蛋白可以与其他途径的转录因子相互作用。
Metazoan cells are exposed to a multitude of signals, which they integrate to determine appropriate developmental or physiological responses. Although the Hippo pathway was only discovered recently, and our knowledge of Hippo signal transduction is far from complete, a wealth of interconnections amongst Hippo and other signaling pathways have already been identified. Hippo signaling is particularly important for growth control, and I describe how integration of Hippo and other pathways contributes to regulation of organ growth. Molecular links between Hippo signaling and other signal transduction pathways are summarized. Different types of mechanisms for signal integration are described, and examples of how the complex interconnections between pathways are used to guide developmental and physiological growth responses are discussed. Features of Hippo signaling appear to make it particularly well suited to signal integration, including its responsiveness to cell-cell contact and the mediation of its transcriptional output by transcriptional co-activator proteins that can interact with transcription factors of other pathways.
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DOI：
10.1073/pnas.1113882109
发表时间：
2012-01-10
影响因子：
11.1
作者：
Chen, Chiao-Lin;Schroeder, Molly C.;Halder, Georg
通讯作者：
Halder, Georg
影响因子：
9.2
作者：
Bennett, F. Christian;Harvey, Kieran F.
通讯作者：
Harvey, Kieran F.
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
64.5
作者：
Alarcón C;Zaromytidou AI;Xi Q;Gao S;Yu J;Fujisawa S;Barlas A;Miller AN;Manova-Todorova K;Macias MJ;Sapkota G;Pan D;Massagué J
通讯作者：
Massagué J
影响因子：
8
作者：
Ferrigno, O;Lallemand, F;Mauviel, A
通讯作者：
Mauviel, A