The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.
The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.
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DOI：
10.3389/fimmu.2016.00621
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发表时间：
2016
影响因子：
7.3
通讯作者：
Fox SB
中科院分区：
文献类型：
--
作者：
Hendry SA;Farnsworth RH;Solomon B;Achen MG;Stacker SA;Fox SB
最近开发的癌症免疫治疗方法，包括免疫检查点抑制剂和嵌合抗原受体T细胞转移，在试验和临床实践中都显示出良好的效果。这些方法反映了人们对肿瘤微环境在癌症发生和发展中的关键作用的日益认识。癌细胞并不是单独行动，而是与它们所处的环境形成一种复杂的关系。宿主对肿瘤的免疫反应是免疫治疗成功的关键；然而，这种反应的决定因素还不完全清楚。肿瘤中的免疫细胞浸润在密度、成分和临床意义上差异很大。肿瘤血管是影响肿瘤行为和治疗反应的微环境的关键组成部分，可以通过使用抗血管生成药物进行靶向治疗。血管内皮细胞和淋巴管内皮细胞在免疫细胞的运输、控制微环境和调节免疫反应中起着重要作用。通过抗血管生成药物改变血管来改善肿瘤的可获得性可能被证明是一种有效的结合免疫治疗方法的策略，可能适用于许多肿瘤类型。在这篇综述中，我们简要讨论了宿主对癌症的免疫反应以及利用这种免疫反应的治疗策略，然后重点讨论了肿瘤血管和淋巴管的病理特征以及它们在肿瘤免疫逃逸中的作用。
Recently developed cancer immunotherapy approaches including immune checkpoint inhibitors and chimeric antigen receptor T cell transfer are showing promising results both in trials and in clinical practice. These approaches reflect increasing recognition of the crucial role of the tumor microenvironment in cancer development and progression. Cancer cells do not act alone, but develop a complex relationship with the environment in which they reside. The host immune response to tumors is critical to the success of immunotherapy; however, the determinants of this response are incompletely understood. The immune cell infiltrate in tumors varies widely in density, composition, and clinical significance. The tumor vasculature is a key component of the microenvironment that can influence tumor behavior and treatment response and can be targeted through the use of antiangiogenic drugs. Blood vascular and lymphatic endothelial cells have important roles in the trafficking of immune cells, controlling the microenvironment, and modulating the immune response. Improving access to the tumor through vascular alteration with antiangiogenic drugs may prove an effective combinatorial strategy with immunotherapy approaches and might be applicable to many tumor types. In this review, we briefly discuss the host’s immune response to cancer and the treatment strategies utilizing this response, before focusing on the pathological features of tumor blood and lymphatic vessels and the contribution these might make to tumor immune evasion.
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影响因子：
4.7
作者：
Bellone M;Calcinotto A
通讯作者：
Calcinotto A
影响因子：
45.3
作者：
Azimi, Farhad;Scolyer, Richard A.;Thompson, John F.
通讯作者：
Thompson, John F.
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
DOI：
10.1073/pnas.95.2.548
发表时间：
1998-01-20
影响因子：
11.1
作者：
Achen, MG;Jeltsch, M;Stacker, SA
通讯作者：
Stacker, SA
影响因子：
64.8
作者：
Bailey, Peter;Chang, David K.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.