Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study.
Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study.
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DOI：
10.1038/ijo.2014.39
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发表时间：
2014-11
影响因子：
4.9
通讯作者：
Boeing, H.
中科院分区：
文献类型：
--
作者：
Floegel, A.;Wientzek, A.;Bachlechner, U.;Jacobs, S.;Drogan, D.;Prehn, C.;Adamski, J.;Krumsiek, J.;Schulze, M. B.;Pischon, T.;Boeing, H.
生活方式因素和中间表型与代谢途径的相互关系尚未解决。我们的目的是在一项基于人群的研究中调查饮食、体力活动、心肺功能和肥胖与血清代谢物网络之间的关系。本研究纳入了2380名来自欧洲癌症与营养前瞻性研究波茨坦随机分组的参与者。靶向代谢组学用于测量127种血清代谢物。其他数据包括人体测量，饮食评估，包括全麦面包，咖啡，蛋糕和饼干的摄入量的食物频率问卷，并客观地测量体力活动的能量消耗和心肺功能的子样本100名参与者。在数据驱动的方法中，使用高斯图形建模来绘制代谢物网络，并描述暴露与血清代谢物之间的相关关联。此外，不同的暴露代谢网络的关系进行了估计。在血清代谢物网络中，可以分离不同的代谢物类别。主要成分为磷脂和酰基肉毒碱，氨基酸和C6-糖。氨基酸与心肺功能和体力活动特别呈正相关。C6-糖和酰基肉毒碱与肥胖呈正相关，与全麦面包的摄入量呈负相关。磷脂与肥胖和咖啡摄入量呈相反的关系。咖啡摄入量和肥胖的代谢网络呈强负相关（体重指数（BMI）：r=-0.57和腰围：r=-0.59）。BMI和腰围的代谢物网络（r=0.99）以及蛋糕和饼干摄入量的代谢物网络与心肺健康和全麦面包摄入量（r=0.52和r=0.50;分别）之间观察到强正相关。生活方式因素和表型似乎在各种代谢途径中相互关联。咖啡的一种可能的保护作用可以通过平衡涉及肝磷脂的肥胖途径来介导。实验研究应验证生物学机制。
It is not yet resolved how lifestyle factors and intermediate phenotypes interrelate with metabolic pathways. We aimed to investigate the associations between diet, physical activity, cardiorespiratory fitness and obesity with serum metabolite networks in a population-based study. The present study included 2380 participants of a randomly drawn subcohort of the European Prospective Investigation into Cancer and Nutrition-Potsdam. Targeted metabolomics was used to measure 127 serum metabolites. Additional data were available including anthropometric measurements, dietary assessment including intake of whole-grain bread, coffee and cake and cookies by food frequency questionnaire, and objectively measured physical activity energy expenditure and cardiorespiratory fitness in a subsample of 100 participants. In a data-driven approach, Gaussian graphical modeling was used to draw metabolite networks and depict relevant associations between exposures and serum metabolites. In addition, the relationship of different exposure metabolite networks was estimated. In the serum metabolite network, the different metabolite classes could be separated. There was a big group of phospholipids and acylcarnitines, a group of amino acids and C6-sugar. Amino acids were particularly positively associated with cardiorespiratory fitness and physical activity. C6-sugar and acylcarnitines were positively associated with obesity and inversely with intake of whole-grain bread. Phospholipids showed opposite associations with obesity and coffee intake. Metabolite networks of coffee intake and obesity were strongly inversely correlated (body mass index (BMI): r=−0.57 and waist circumference: r=−0.59). A strong positive correlation was observed between metabolite networks of BMI and waist circumference (r=0.99), as well as the metabolite networks of cake and cookie intake with cardiorespiratory fitness and intake of whole-grain bread (r=0.52 and r=0.50; respectively). Lifestyle factors and phenotypes seem to interrelate in various metabolic pathways. A possible protective effect of coffee could be mediated via counterbalance of pathways of obesity involving hepatic phospholipids. Experimental studies should validate the biological mechanisms.
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影响因子：
--
作者：
Krumsiek J;Suhre K;Illig T;Adamski J;Theis FJ
通讯作者：
Theis FJ
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
12.6
作者：
Bravi, Francesca;Bosetti, Cristina;La Vecchia, Carlo
通讯作者：
La Vecchia, Carlo
影响因子：
7.7
作者：
Boeing, H;BohlscheidThomas, S;Wahrendorf, J
通讯作者：
Wahrendorf, J