Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer.
Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer.
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DOI：
10.3389/fonc.2021.682217
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Du W;Pasca di Magliano M;Zhang Y
间质丰富的免疫抑制微环境是胰腺导管腺癌（PDA）的标志。肿瘤细胞和肿瘤微环境的其他细胞组分，例如癌症相关的成纤维细胞、CD4+ T细胞和骨髓细胞，通过相互作用的网络连接。它们的相互作用不仅导致PDA的免疫逃避，而且还有助于胰腺癌细胞的可塑性、侵袭性、转移性、化疗抗性、免疫治疗抗性和放射治疗抗性。在这篇综述中，我们描述了PDA微环境中基质细胞的几个流行群体，并描述了它们之间的串扰如何驱动和维持免疫抑制。我们还总结了针对间质的治疗方法。随着对PDA中复杂的细胞和分子网络的更好理解，可以设计旨在通过重新编程肿瘤微环境使PDA对化疗或免疫疗法敏感的策略，从而改善胰腺癌患者的临床治疗。
The stroma-rich, immunosuppressive microenvironment is a hallmark of pancreatic ductal adenocarcinoma (PDA). Tumor cells and other cellular components of the tumor microenvironment, such as cancer associated fibroblasts, CD4+ T cells and myeloid cells, are linked by a web of interactions. Their crosstalk not only results in immune evasion of PDA, but also contributes to pancreatic cancer cell plasticity, invasiveness, metastasis, chemo-resistance, immunotherapy-resistance and radiotherapy-resistance. In this review, we characterize several prevalent populations of stromal cells in the PDA microenvironment and describe how the crosstalk among them drives and maintains immune suppression. We also summarize therapeutic approaches to target the stroma. With a better understanding of the complex cellular and molecular networks in PDA, strategies aimed at sensitizing PDA to chemotherapy or immunotherapy through re-programing the tumor microenvironment can be designed, and in turn lead to improved clinical treatment for pancreatic cancer patients.
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影响因子：
5.8
作者：
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通讯作者：
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DOI：
10.1084/jem.20150950
发表时间：
2016-05-02
期刊：
The Journal of experimental medicine
影响因子：
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Faccio R
影响因子：
15.9
作者：
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通讯作者：
di Magliano, Marina Pasca