Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population-based study.
Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population-based study.
复制标题
佩吉特病的临床病理特征和生存结果：一项基于 SEER 人群的研究
DOI：
10.1002/cam4.1475
复制
发表时间：
2018-06
期刊：
影响因子：
4
通讯作者：
Jin W
中科院分区：
文献类型：
--
作者：
Zhao Y;Sun HF;Chen MT;Gao SP;Li LD;Jiang HL;Jin W
本研究的目的是探讨佩吉特病（PD）、佩吉特病伴浸润性导管癌（PD-IDC）和佩吉特病伴导管内癌（PD-DCIS）的临床病理学特征和生存结局。我们在2000年至2013年的监测、流行病学和最终结果（SEER）数据库中确定了501，631例女性患者。这些确定的患者包括PD患者（n = 469）、PD-IDC患者（n = 1832）、PD-DCIS患者（n = 1130）和浸润性导管癌（IDC）患者（n = 498，076）。然后，我们将这些患者的临床特征与同期诊断为IDC的患者进行比较。乳腺癌的这些亚型的结果是不同的。基于总生存期，PD‐IDC患者的预后最差（5年生存率= 84.1%）。PD-DCIS的预后最好（5年生存率= 97.5%）。此外，在佩吉特病患者中，已婚者的预后比未婚者更好。而且，根据我们的研究，婚姻状况与PD-IDC患者的激素受体状态相关。在佩吉特病的三种亚型中，PD‐IDC患者的预后最差。此外，未婚患者的预后更差。PD-IDC患者的婚姻状况与激素状态相关。这一观察结果强调了个体化治疗的重要性。
The objective of this study was to investigate the clinicopathological characteristics and survival outcomes of Paget disease (PD), Paget disease concomitant infiltrating duct carcinoma (PD‐IDC), and Paget disease concomitant intraductal carcinoma (PD‐DCIS). We identified 501,631 female patients from 2000 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. These identified patients included patients with PD (n = 469), patients with PD‐IDC (n = 1832), and patients with PD‐DCIS (n = 1130) and infiltrating ductal carcinoma (IDC) (n = 498,076). Then, we compared the clinical characteristics of these patients with those who were diagnosed with IDC during the same period. The outcomes of these subtypes of breast carcinoma were different. Based on the overall survival, the patients with PD‐IDC had the worst prognosis (5‐year survival rate = 84.1%). The PD‐DCIS had the best prognosis (5‐year survival rate = 97.5%). Besides, among patients with Paget disease, the one who was married had a better prognosis than who were not. And, according to our research, the marital status was associated with the hormone receptor status in patients with PD‐IDC. Among three subtypes of Paget disease, patients with PD‐IDC had the worst prognosis. Besides, patients who were unmarried had worse outcomes. And the marital status of patients with PD‐IDC is associated with hormone status. The observation underscores the importance of individualized treatment.
登录
查看更多内容
DOI：
10.1097/00129039-200306000-00005
发表时间：
2003-06-01
影响因子：
1.6
作者：
Anderson, JM;Ariga, R;Gattuso, P
通讯作者：
Gattuso, P
影响因子：
10.3
作者：
Schelfhout, VRJ;Coene, ED;De Potter, CR
通讯作者：
De Potter, CR
影响因子：
3.3
作者：
Turner-Cobb, JM;Sephton, SE;Spiegel, D
通讯作者：
Spiegel, D
影响因子：
5.6
作者：
Johnson, NJ;Backlund, E;Loveless, CA
通讯作者：
Loveless, CA
影响因子：
5.4
作者：
Kravdal, O
通讯作者：
Kravdal, O