Vinorelbine induced perforation of a metastatic gastric lesion.
Vinorelbine induced perforation of a metastatic gastric lesion.
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DOI：
10.1007/s11845-016-1536-1
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发表时间：
2017-08
影响因子：
2.1
通讯作者：
O'Reilly S
中科院分区：
文献类型：
--
作者：
Mullally WJ;O'Súilleabháin CB;Brady C;O'Reilly S
乳腺癌转移至胃肠道的情况很少见，且与小叶癌的相关性高于导管癌（Borst 和 Ingold，Surg 114(4):637–641）。本文的目的是对一种独特的胃肠道转移进行病例回顾和文献综述。一名 46 岁的女士患有转移性浸润性导管乳腺癌，因突然出现上腹和左肩疼痛而被送往急症室。她于 1 周前完成了卡培他滨/长春瑞滨的第一个周期。临床检查发现上腹部压痛，上腹部强直。经放射学鉴定，隔膜下方存在游离空气，且 Rigler 征呈阳性。腹腔镜检查显示左上腹有纤维蛋白渗出物，与小曲率胃穿孔一致。随后的食管胃十二指肠镜检查（OGD）显示胃溃疡已愈合，外观良性；然而病理证实转移性乳腺癌。文献综述证实之前没有报道过长春瑞滨诱发胃穿孔的病例。发现四例转移性乳腺癌合并胃转移并出现穿孔；其中 3 例（Fra 等人，Presse Med 25(26):1215 (1996)、Solis-Caxaj 等人，Gastroenterol Clin Biol 28(1):91–92 (2004)、Ghosn 等人，Bull Cancer 78(11):1071–1073 (1991)）出现在法国医学文献中，其中包括一名男性患者(Fra 等人，Presse Med 25(26)：1215 (1996))和至少一种导管性乳腺癌(Solis-Caxaj 等人，Gastroenterol Clin Biol 28(1)：91-92 (2004))。第四个病例（van Geel 等人，Ned Tijdschr Geneeskd 144(37):1761–1763 (2000)）是荷兰医学文献中的小叶乳腺癌。该病例代表乳腺癌化疗的罕见并发症，患者随后从治疗中获得的显着益处与对导致胃穿孔的治疗的化疗敏感性一致。胃穿孔五年后，在序贯激素治疗进展后，她恢复了姑息化疗。
Breast carcinoma metastasis to the gastrointestinal tract is rare and more frequently associated with lobular than ductal carcinoma (Borst and Ingold, Surg 114(4):637–641). The purpose of this article is to present a case based review of a unique gastrointestinal metastasis and literature review. A 46 year old lady with metastatic invasive ductal breast cancer was admitted to A&E with sudden onset of epigastric and left shoulder pain. She completed the first cycle of capecitabine/vinorelbine 1 week previously. Clinical examination revealed a tender epigastrium with rigidity in the upper abdomen. Free air under the diaphragm and a positive Rigler’s sign was radiologically identified. A laparoscopy demonstrated a fibrinous exudate in the left upper quadrant consistent with a walled off lesser curvature gastric perforation. A subsequent oesophagogastroduodenoscopy (OGD) demonstrated a healed gastric ulcer of benign appearance; however the pathology confirmed metastatic breast carcinoma. Literature review confirmed no previously reported cases of vinorelbine induced gastric perforation. Four cases of metastatic breast cancer with gastric metastasis presenting with perforation were identified; three of these cases (Fra et al., Presse Med 25(26):1215 (1996), Solis-Caxaj et al., Gastroenterol Clin Biol 28(1):91–92 (2004), Ghosn et al., Bull Cancer 78(11):1071–1073 (1991)), were in the French medical literature, including one male patient (Fra et al., Presse Med 25(26):1215 (1996)) and at least one ductal breast carcinoma (Solis-Caxaj et al., Gastroenterol Clin Biol 28(1):91–92 (2004)). The fourth case (van Geel et al., Ned Tijdschr Geneeskd 144(37):1761–1763 (2000)), was in the Dutch medical literature and a lobular breast carcinoma. This case represents a rare complication of breast cancer chemotherapy, the subsequent significant benefit the patient received from treatment is consistent with the chemosensitivity to therapy that also resulted in gastric perforation. Five years after gastric perforation she resumed palliative chemotherapy after progression on sequential hormonal therapies.
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影响因子：
2.8
作者：
Honma, Naoko;Takubo, Kaiyo;Sakamoto, Goi
通讯作者：
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影响因子：
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3.7
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