The renin angiotensin aldosterone system and insulin resistance in humans.
The renin angiotensin aldosterone system and insulin resistance in humans.
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DOI：
10.1007/s11906-012-0323-2
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发表时间：
2013-02
影响因子：
5.6
通讯作者：
Adler, Gail K.
中科院分区：
文献类型：
--
作者：
Underwood, Patricia C.;Adler, Gail K.
关键词：
Renin angiotensin aldosterone systemAngiotensin IIInsulin resistanceAldosteroneInsulin signalingAngiotensin converting enzymeAngiotensin 1-7Diabetes mellitusGlucose metabolismSkeletal muscleAdipocytesPancreasInsulin secretionInflammationGeneticsPolymorphismsAngiotensin II receptor blockerAngiotensin converting enzyme inhibitorInsulin sensitivityHuman studiesAnimal modelsRenin inhibitorObesityHypertensionClinical trials
Alterations in the renin angiotensin aldosterone system (RAAS) contribute to the underlying pathophysiology of insulin resistance in humans; however, individual differences in the treatment response of insulin resistance to RAAS blockade persist. Thus, understanding inter-individual differences in the relationship between the RAAS and insulin resistance may provide insights into improved personalized treatments and improved outcomes. The effects of the systemic RAAS on blood pressure regulation and glucose metabolism have been studied extensively; however, recent discoveries on the influence of local tissue RAAS in the skeletal muscle, heart, vasculature, adipocytes, and pancreas have led to an improved understanding of how activated tissue RAAS influences the development of insulin resistance and diabetes in humans. Angiotensin II (ANGII) is the predominant RAAS component contributing to insulin resistance; however, other players such as aldosterone, renin, and ACE2 are also involved. This review examines the role of local ANGII activity on insulin resistance development in skeletal muscle, adipocytes, and pancreas, followed by a discussion of the other RAAS components implicated in insulin resistance, including ACE2, Ang1-7, renin, and aldosterone.
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影响因子：
2.1
作者：
Chen, Ying-Hsin;Liu, Jui-Ming;Yu, Cheng-Ping
通讯作者：
Yu, Cheng-Ping
血管紧张素 II 1 型和 2 型受体调节基底骨骼肌微血管容量和葡萄糖使用
影响因子：
8.3
作者：
Chai, Weidong;Wang, Wenhui;Liu, Zhenqi
通讯作者：
Liu, Zhenqi
影响因子：
3
作者：
CHAPPELL, MC;JACOBSEN, DW;TALLANT, EA
通讯作者：
TALLANT, EA
影响因子：
4.1
作者：
Bindom SM;Lazartigues E
通讯作者：
Lazartigues E
影响因子：
16.2
作者：
Bonnet, Fabrice;Patel, Sheila;Walker, Mark
通讯作者：
Walker, Mark