The sweeter side of ACE2: physiological evidence for a role in diabetes.
The sweeter side of ACE2: physiological evidence for a role in diabetes.
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DOI：
10.1016/j.mce.2008.09.020
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发表时间：
2009-04-29
影响因子：
4.1
通讯作者：
Lazartigues E
中科院分区：
文献类型：
--
作者：
Bindom SM;Lazartigues E
糖尿病在世界各地都是一个日益严重的问题。I型和II型糖尿病的临床试验和动物模型都表明，血管紧张素-II(Ang-II)信号通路的过度活跃有助于糖尿病和糖尿病并发症的发生。与临床相关的是，阻断肾素-血管紧张素系统可预防新发糖尿病并降低糖尿病并发症的风险。血管紧张素转换酶(ACE)2是新近发现的一种单羧基肽酶，是ACE的第一个同源物。它被认为主要通过裂解Ang-II产生Ang-(1-7)来抑制Ang-II信号转导通路，Ang-(1-7)的作用与Ang-II相反，并由Mas受体介导。这种酶存在于肾脏、肝脏、脂肪组织和胰腺中。在糖尿病和糖尿病肾病早期，其在内分泌胰腺中的表达升高。ACE2被认为在糖尿病和糖尿病肾病中都以代偿方式起作用。最近，我们发现在小鼠胰腺中存在Mas受体，并观察到ACE2基因敲除小鼠的Mas受体免疫反应性降低和空腹血糖水平升高，表明这些小鼠可能是研究ACE2在糖尿病中作用的新模型。在这篇综述中，我们将研究肾素-血管紧张素系统在糖尿病的生理病理和治疗中的作用，并强调ACE2/Ang-(1-7)/mas受体轴的潜在好处，重点是关于ACE2的最新数据。
Diabetes mellitus is a growing problem in all parts of the world. Both clinical trials and animal models of type I and type II diabetes have shown that hyperactivity of angiotensin-II (Ang-II) signaling pathways contribute to the development of diabetes and diabetic complications. Of clinical relevance, blockade of the renin–angiotensin system prevents new-onset diabetes and reduces the risk of diabetic complications. Angiotensin-converting enzyme (ACE) 2 is a recently discovered mono-carboxypeptidase and the first homolog of ACE. It is thought to inhibit Ang-II signaling cascades mostly by cleaving Ang-II to generate Ang-(1–7), which effects oppose Ang-II and are mediated by the Mas receptor. The enzyme is present in the kidney, liver, adipose tissue and pancreas. Its expression is elevated in the endocrine pancreas in diabetes and in the early phase during diabetic nephropathy. ACE2 is hypothesized to act in a compensatory manner in both diabetes and diabetic nephropathy. Recently, we have shown the presence of the Mas receptor in the mouse pancreas and observed a reduction in Mas receptor immuno-reactivity as well as higher fasting blood glucose levels in ACE2 knockout mice, indicating that these mice may be a new model to study the role of ACE2 in diabetes. In this review we will examine the role of the renin–angiotensin system in the physiopathology and treatment of diabetes and highlight the potential benefits of the ACE2/Ang-(1–7)/Mas receptor axis, focusing on recent data about ACE2.
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影响因子：
8.2
作者：
ATEF, N;PORTHA, B;PENICAUD, L
通讯作者：
PENICAUD, L
影响因子：
7.7
作者：
Dalla Vestra, M;Masiero, A;Fioretto, P
通讯作者：
Fioretto, P
DOI：
10.1590/s0100-879x2000000600012
发表时间：
2000-06-01
影响因子：
2.3
作者：
Almeida, AP;Frábregas, BC;Santos, RAS
通讯作者：
Santos, RAS
影响因子：
7.7
作者：
Carlsson, PO;Jansson, L;Kallskog, O
通讯作者：
Kallskog, O
影响因子：
20.1
作者：
Donoghue, M;Hsieh, F;Acton, S
通讯作者：
Acton, S