Interspecies variation in hominid gut microbiota controls host gene regulation.
Interspecies variation in hominid gut microbiota controls host gene regulation.
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人类肠道菌群的种间变异控制宿主基因调控。
DOI：
10.1016/j.celrep.2021.110057
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发表时间：
2021-11-23
期刊：
影响因子：
8.8
通讯作者：
Blekhman R
中科院分区：
文献类型：
--
作者：
Muehlbauer AL;Richards AL;Alazizi A;Burns MB;Gomez A;Clayton JB;Petrzelkova K;Cascardo C;Resztak J;Wen X;Pique-Regi R;Luca F;Blekhman R
肠道微生物组在原始人类宿主之间表现出极端的组成变化。然而，目前尚不清楚这种变异如何影响跨物种的宿主生理学，以及这种效应是否可以通过相互作用的上皮细胞中宿主基因表达的微生物调节来介导。在这里，我们的特点是人类结肠上皮细胞在体外活的微生物群落从人类，黑猩猩，大猩猩和猩猩提取的转录反应。我们发现大多数宿主基因表现出保守的反应，它们对四种原始人类微生物的反应相似。然而，数百种宿主基因表现出不同的反应，它们只对特定宿主物种的微生物组做出反应。这些基因与人类肠道疾病有关，包括炎症性肠病和克罗恩病。最后，我们发现炎症相关的微生物物种调节先前与炎症性肠病相关的宿主基因的表达，这表明人类物种特异性宿主-微生物组相互作用的健康相关后果。Muehlbauer等人研究了不同原始人类微生物组之间的差异如何驱动结肠上皮细胞培养物中的宿主基因表达。他们发现，仅对特定原始人类物种的微生物组产生反应的宿主基因与胃肠道疾病有关，这对理解微生物组如何影响人类健康具有重要意义。
The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific host species. Such genes are associated with intestinal diseases in humans, including inflammatory bowel disease and Crohn’s disease. Last, we find that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids. Muehlbauer et al. investigate how variation between different hominid microbiomes drives host gene expression in colonic epithelial cell cultures. They find that host genes that respond only to microbiomes from a specific hominid species are linked to gastrointestinal diseases, suggesting implications for understanding how the microbiome can impact human health.
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影响因子：
48
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通讯作者：
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影响因子：
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