A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects.
A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects.
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DOI：
10.1016/j.jnutbio.2008.08.004
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发表时间：
2009-11
影响因子：
5.6
通讯作者：
Yin, Xinmin
中科院分区：
文献类型：
--
作者：
Jiang, Qing;Moreland, Michelle;Ames, Bruce N.;Yin, Xinmin
非甾体抗炎药如阿司匹林用于缓解疼痛和癌症的化学预防，但经常导致胃粘膜损伤。我们研究了阿司匹林和α-生育酚（αT）或γ-生育酚（γT）（两种主要形式的维生素E）的组合是否比阿司匹林单独使用更好的抗炎作用，以及这些组合是否减轻了阿司匹林相关的副作用。在角叉菜胶致大鼠气囊炎模型中，阿司匹林（150 mg/kg）或阿司匹林与γT（33 mg/kg）联合应用，在炎症开始后6 h，可抑制炎症部位促炎性前列腺素E2（PGE 2）的70%（P<0.02）。但在18小时，仅联合用药减少了炎症部位收集的液体中的渗出量（15%，P<0.05），并显示出适度的PGE 2抑制（40%，P<0.07）和乳酸脱氢酶活性抑制（30%，P=0.07）。γT（但不是αT）可以减轻阿司匹林引起的食物摄入量减少，部分逆转阿司匹林抑制的胃PGE 2并减轻胃部病变。令人惊讶的是，阿司匹林和αT（33 mg/kg）的组合并没有显示出比阿司匹林单独使用更多的益处，但会加重胃损伤和食物摄入量减少。我们的研究表明，阿司匹林和γT联合使用，而不是αT，在抗炎作用和减轻阿司匹林引起的不良反应方面优于阿司匹林单独使用。这种组合可能有助于补充阿司匹林治疗慢性炎症和癌症。
Non-steroidal anti-inflammatory drugs such as aspirin are used for pain relief and chemoprevention against cancer, but frequently cause gastric mucosal injury. We examined whether combinations of aspirin and alpha-tocopherol (αT) or gamma-tocopherol (γT), two major forms of vitamin E, are better anti-inflammatories than aspirin alone and whether these combinations alleviate aspirin-associated side effects. In the carrageenan-induced air-pouch inflammation model in the rat, aspirin (150mg/kg) or a combination of aspirin and γT (33mg/kg) inhibited proinflammatory prostaglandin E2 (PGE2) by 70% (P<0.02) at the inflammation site at six hours after inflammation was initiated. But at 18 hours, only the combination decreased exudate volume (15%, P<0.05), and showed modest inhibition of PGE2 (40%, P<0.07) and lactate dehydrogenase activity (30%, P=0.07), in the fluid collected at the inflammation site. γT but not αT spared aspirin-caused reduction of food intake, partially reversed aspirin-depressed gastric PGE2 and attenuated stomach lesions. Surprisingly, the combination of aspirin and αT (33mg/kg) did not show more benefits than aspirin alone, but worsened gastric injury and food-intake reduction. Our study demonstrated that a combination of aspirin and γT, but not αT, has some advantage over aspirin alone in the anti-inflammatory effect and attenuation of the aspirin-caused adverse effect. This combination may be useful to complement aspirin in the treatment of chronic inflammatory conditions and cancer.
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影响因子：
158.5
作者：
GIOVANNUCCI, E;EGAN, KM;SPEIZER, FE
通讯作者：
SPEIZER, FE
影响因子：
7.4
作者：
Jiang, Q;Lykkesfeldt, J;Ames, BN
通讯作者：
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影响因子：
4.4
作者：
Liede, KE;Haukka, JK;Heinonen, OP
通讯作者：
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影响因子：
6.5
作者：
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通讯作者：
Yin, Xinmin
DOI：
10.1073/pnas.200357097
发表时间：
2000-10-10
影响因子：
11.1
作者：
Jiang, Q;Elson-Schwab, I;Ames, BN
通讯作者：
Ames, BN