Exploration of Lipid Metabolism in Gastric Cancer: A Novel Prognostic Genes Expression Profile.
Exploration of Lipid Metabolism in Gastric Cancer: A Novel Prognostic Genes Expression Profile.
复制标题
DOI：
10.3389/fonc.2021.712746
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Cai M
中科院分区：
文献类型：
--
作者：
Xiong Z;Lin Y;Yu Y;Zhou X;Fan J;Rog CJ;Cai K;Wang Z;Chang Z;Wang G;Tao K;Cai M
脂质代谢的改变越来越被认识到。然而，脂质代谢在胃癌预后中的应用尚未得到探索。从肿瘤基因组图谱（TCGA）的GC队列中分析了204个脂代谢相关基因，并从GEO（Gene Expression Omnibus）的4个独立队列和武汉协和医院的1个队列中进行了外部验证。在GC和正常组织之间进行差异表达和富集分析。应用LASSO-Cox比例风险回归模型选择预后基因并构建基因表达谱。我们的研究表明AKR 1B 1、PLD 1和UGT 8的高表达水平与胃癌患者的预后不良相关，而AGPAT 3的高表达水平与胃癌患者的预后良好相关。此外，我们开发了由AGPAT 3、AKR 1B 1、PLD 1和UGT 8组成的基因谱，表明三组在总生存期（OS）方面具有显著差异。在独立队列中成功验证了该特征，并在免疫组化队列中表现良好。此外，我们发现，醚脂代谢，甘油磷脂代谢和甘油脂代谢上调，脂肪酸β-氧化和其他脂质过氧化过程减少在GC。总的来说，我们发现脂代谢是可靠的，并在临床上适用于预测GC的预后基于一个新的基因谱。
Alterations in lipid metabolism are increasingly being recognized. However, the application of lipid metabolism in the prognosis of gastric cancer (GC) has not yet been explored. A total of 204 lipid metabolism relative genes were analyzed in the GC cohort from The Cancer Genome Atlas (TCGA), and four independent cohorts from Gene Expression Omnibus (GEO) and one cohort from Wuhan Union Hospital were applied for external validation. Differential expression and enrichment analyses were performed between GC and normal tissue. The LASSO-Cox proportional hazard regression model was applied to select prognostic genes and to construct a gene expression profile. Our research indicated that higher expression level of AKR1B1, PLD1, and UGT8 were correlated with worse prognosis of GC patients, while AGPAT3 was correlated with better prognosis. Furthermore, we developed a gene profile composed of AGPAT3, AKR1B1, PLD1, and UGT8 suggested three groups with a significant difference in overall survival (OS). The profile was successfully validated in an independent cohort and performed well in the immunohistochemical cohort. Furthermore, we found that ether lipid metabolism, glycerophospholipid metabolism, and glycerolipid metabolism were upregulated, and fatty acid β-oxidation and other lipid peroxidation processes were reduced in GC. Collectively, we found lipid metabolism is reliable and clinically applicable in predicting the prognosis of GC based on a novel gene profile.
登录
查看更多内容
影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
AKR1B1 通过激活 EMT 程序的正反馈环促进基底样乳腺癌进展
DOI：
10.1084/jem.20160903
发表时间：
2017-04-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wu X;Li X;Fu Q;Cao Q;Chen X;Wang M;Yu J;Long J;Yao J;Liu H;Wang D;Liao R;Dong C
通讯作者：
Dong C
DOI：
10.1186/s40880-018-0301-4
发表时间：
2018-05-21
期刊：
Cancer communications (London, England)
影响因子：
--
作者：
Cheng C;Geng F;Cheng X;Guo D
通讯作者：
Guo D
抑制 UGT8 通过减弱硫苷脂-α V β 5 轴抑制基底样乳腺癌进展
DOI：
10.1084/jem.20172048
发表时间：
2018-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cao Q;Chen X;Wu X;Liao R;Huang P;Tan Y;Wang L;Ren G;Huang J;Dong C
通讯作者：
Dong C
影响因子：
9.3
作者：
Li F;Yoshizawa JM;Kim KM;Kanjanapangka J;Grogan TR;Wang X;Elashoff DE;Ishikawa S;Chia D;Liao W;Akin D;Yan X;Lee MS;Choi R;Kim SM;Kang SY;Bae JM;Sohn TS;Lee JH;Choi MG;Min BH;Lee JH;Kim JJ;Kim Y;Kim S;Wong DTW
通讯作者：
Wong DTW