Altered white matter diffusivity and subtle motor function in a pilot cohort of adolescents with sports-related concussion.
Altered white matter diffusivity and subtle motor function in a pilot cohort of adolescents with sports-related concussion.
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运动相关脑震荡青少年飞行员队列中脑白质弥散性和细微运动功能的改变。
DOI：
10.1080/02699052.2022.2034181
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发表时间：
2022-02-23
期刊：
影响因子：
1.9
通讯作者：
Suskauer, Stacy J.
中科院分区：
文献类型：
--
作者：
Crasta, Jewel E.;Tucker, Robert N.;Robinson, Joshua;Chen, Hsuan Wei;Crocetti, Deana;Suskauer, Stacy J.
运动相关脑震荡（SRC）青少年表现出急性和持续的微妙运动功能缺陷。然而，对相关神经基础的研究有限。这项初步研究使用扩散张量成像（DTI）检查了运动相关白色物质通路的变化及其与细微运动功能的关系。12名SRC青少年（12-17岁）在受伤后两周内和13名从未受伤的神经典型同龄人完成了DTI扫描。6名患有SRC的青少年在脑震荡医疗许可后返回进行随访。微妙的运动功能进行了评估，使用身体和神经检查微妙的迹象（PANESS）。与对照组相比，SRC青少年的上级放射冠的平均扩散率（MD）更高，微妙的运动缺陷更大。在所有参与者中，更大的细微运动缺陷与上级放射冠的更高（更不典型）MD相关。初步纵向分析表明，从首次访视到医疗许可后的随访访视，胼胝体各向异性分数降低，但上级放射冠MD无变化。这些研究结果支持初步证据的大脑行为之间的关系上级冠辐射微结构和微妙的运动缺陷，青少年SRC值得进一步调查。
Adolescents with sports-related concussion (SRC) demonstrate acute and persistent deficits in subtle motor function. However, there is limited research examining related neurological underpinnings. This pilot study examined changes in motor-associated white matter pathways using diffusion tensor imaging (DTI) and their relationship with subtle motor function. Twelve adolescents with SRC (12–17 years) within two-weeks post-injury and 13 never-injured neurotypical peers completed DTI scanning. A subset of 6 adolescents with SRC returned for a follow-up visit post-medical clearance from concussion. Subtle motor function was evaluated using the Physical and Neurological Examination of Subtle Signs (PANESS). Adolescents with SRC showed higher mean diffusivity (MD) of the superior corona radiata and greater subtle motor deficits compared to controls. Across all participants, greater subtle motor deficits were associated with higher (more atypical) MD of the superior corona radiata. Preliminary longitudinal analysis indicated reduction in fractional anisotropy of the corpus callosum but no change in the MD of the superior corona radiata from the initial visit to the follow-up visit post-medical clearance. These findings support preliminary evidence for a brain–behavior relationship between superior corona radiata microstructure and subtle motor deficits in adolescents with SRC that merits further investigation.
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影响因子：
1.4
作者：
Stephens JA;Davies PL;Gavin WJ;Mostofsky SH;Slomine BS;Suskauer SJ
通讯作者：
Suskauer SJ
DOI：
10.1097/phm.0000000000001589
发表时间：
2021-06-01
影响因子：
3
作者：
Crasta JE;Raja AE;Caffo BS;Hluchan CM;Suskauer SJ
通讯作者：
Suskauer SJ
影响因子：
4.2
作者：
Borich, Michael;Makan, Nadia;Virji-Babul, Naznin
通讯作者：
Virji-Babul, Naznin
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
4.2
作者：
Bartnik-Olson, Brenda L.;Holshouser, Barbara;Ashwal, Stephen
通讯作者：
Ashwal, Stephen