Electrical synapses and their functional interactions with chemical synapses.

Electrical synapses and their functional interactions with chemical synapses.
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DOI:
10.1038/nrn3708
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发表时间:
2014-04
影响因子:
34.7
通讯作者:
Pereda, Alberto E.
Pereda, Alberto E.
中科院分区:
医学1区
文献类型:
--
作者:
Pereda, Alberto E.

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大脑的功能依赖于神经元相互沟通的能力。神经元间的交流主要发生在突触上,在那里,一个神经元的信息迅速传递到另一个神经元。突触传递主要有两种方式:化学方式和电方式。越来越多的证据表明,无论是在发育过程中还是在成年大脑中,这两种突触传递方式都密切相互作用,而不是独立运作或服务于不相关的功能。本文强调突触传递既包括化学传递也包括电传递,这两种形式的神经元间通信之间的相互作用可能是正常大脑发育和功能所必需的,而不是将突触传递理解为化学传递或电传递。
Brain function relies on the ability of neurons to communicate with each other. Interneuronal communication primarily takes place at synapses, where information from one neuron is rapidly conveyed to a second neuron. There are two main modalities of synaptic transmission: chemical and electrical. Far from functioning independently and serving unrelated functions, mounting evidence indicates that these two modalities of synaptic transmission closely interact, both during development and in the adult brain. Rather than conceiving synaptic transmission as either chemical or electrical, this article emphasizes the notion that synaptic transmission is both chemical and electrical and that interactions between these two forms of interneuronal communication might be required for normal brain development and function.
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