The role of extracellular vesicles when innate meets adaptive.
The role of extracellular vesicles when innate meets adaptive.
复制标题
DOI：
10.1007/s00281-018-0681-1
复制
发表时间：
2018-09
影响因子：
9
通讯作者：
Wauben MHM
中科院分区：
文献类型：
--
作者：
Groot Kormelink T;Mol S;de Jong EC;Wauben MHM
先天免疫细胞因其对身体抵御入侵病原体和有害物质的第一道防线的快速和关键贡献而被公认。这些作用可以通过适应激活刺激的特异性适应性免疫反应进一步放大。最近，人们越来越认识到，几乎所有的先天免疫细胞，即，肥大细胞、嗜中性粒细胞、巨噬细胞、嗜酸性粒细胞、嗜碱性粒细胞和NK细胞能够与树突细胞（DC）和/或T和B细胞通讯，从而显著促进适应性免疫应答的协调。到目前为止，主要与这种功能相关的通信手段是细胞-细胞接触和广泛的可溶性介质的释放。此外，先天免疫细胞衍生的细胞外囊泡（EV）的调制适应性免疫的可能贡献将概述在此审查。EV是由脂质双层、蛋白质和核酸组成的亚微米颗粒，由细胞以调节的方式释放。EV参与多种细胞类型之间的细胞间通讯，包括免疫系统的细胞。对先天免疫细胞衍生的EV影响适应性免疫应答或反之亦然的机制的良好理解，可以揭示免疫系统调节的新见解，并可以为EV（或其组分）在控制免疫应答中开辟新的可能性，无论是作为治疗，靶标，还是作为未来免疫调节治疗中的佐剂。
Innate immune cells are recognized for their rapid and critical contribution to the body’s first line of defense against invading pathogens and harmful agents. These actions can be further amplified by specific adaptive immune responses adapted to the activating stimulus. Recently, the awareness has grown that virtually all innate immune cells, i.e., mast cells, neutrophils, macrophages, eosinophils, basophils, and NK cells, are able to communicate with dendritic cells (DCs) and/or T and B cells, and thereby significantly contribute to the orchestration of adaptive immune responses. The means of communication that are thus far primarily associated with this function are cell-cell contacts and the release of a broad range of soluble mediators. Moreover, the possible contribution of innate immune cell-derived extracellular vesicles (EVs) to the modulation of adaptive immunity will be outlined in this review. EVs are submicron particles composed of a lipid bilayer, proteins, and nucleic acids released by cells in a regulated fashion. EVs are involved in intercellular communication between multiple cell types, including those of the immune system. A good understanding of the mechanisms by which innate immune cell-derived EVs influence adaptive immune responses, or vice versa, may reveal novel insights in the regulation of the immune system and can open up new possibilities for EVs (or their components) in controlling immune responses, either as a therapy, target, or as an adjuvant in future immune modulating treatments.
登录
查看更多内容
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.4
作者：
Byrne, Scott N.;Limon-Flores, Alberto Y.;Ullrich, Stephen E.
通讯作者：
Ullrich, Stephen E.
影响因子：
20.3
作者：
Dalli, Jesmond;Norling, Lucy V.;Perretti, Mauro
通讯作者：
Perretti, Mauro
影响因子：
8
作者：
Chu, D. K.;Mohammed-Ali, Z.;Jordana, M.
通讯作者：
Jordana, M.
影响因子：
5.5
作者：
Antonio Canas, Jose;Sastre, Beatriz;del Pozo, Victoria
通讯作者：
del Pozo, Victoria