Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.
Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.
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DOI：
10.1007/s10654-018-0364-1
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发表时间：
2018-05
影响因子：
13.6
通讯作者：
Lifepath Consortium
中科院分区：
文献类型：
--
作者：
Castagné R;Garès V;Karimi M;Chadeau-Hyam M;Vineis P;Delpierre C;Kelly-Irving M;Lifepath Consortium
稳态负荷（AL）的概念是指在生命周期中通过应激反应系统适应环境而产生的整体生理“磨损”的概念。社会经济地位 (SEP) 与死亡率之间的联系现已确立，并且有证据表明 AL 可能捕捉到 SEP 与死亡率之间的联系。为了定量评估 AL 对死亡率的作用，我们使用 1958 年英国出生队列的数据，其中包括 8,113 名成年人的 11 年死亡率。具体来说，我们质疑累积生物风险（非稳态负荷）的假设，该风险反映了可能预测未来死亡风险的 4 个生理系统（N = 132）。 AL 的定义是使用 44 岁时采集的生物样本中的血液中的 14 种生物标志物进行测定。 Cox 比例风险回归分析显示，44 岁时较高的别静态负荷是 11 年后死亡率的显着预测因子 [HR = 3.56（2.3 至 5.53）]。我们发现这种关系不仅仅与生命早期的 SEP、不良童年经历和成年早期的健康状况、行为和 SEP 有关 [HR = 2.57（1.59 至 4.15）]。关于每个生理系统和生物标志物预测未来死亡的能力，我们的结果表明，与单独评估每个生理系统子评分和生物标志物相比，累积测量是有利的。我们的研究结果增加了一些证据，证明生物体现是对压力的反应，最终影响死亡率。本文的在线版本 (10.1007/s10654-018-0364-1) 包含补充材料，可供授权用户使用。
The concept of allostatic load (AL) refers to the idea of a global physiological ‘wear and tear’ resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults. Specifically, we interrogate the hypothesis of a cumulative biological risk (allostatic load) reflecting 4 physiological systems potentially predicting future risk of death (N = 132). AL was defined using 14 biomarkers assayed in blood from a biosample collected at 44 years of age. Cox proportional hazard regression analysis revealed that higher allostatic load at 44 years old was a significant predictor of mortality 11 years later [HR = 3.56 (2.3 to 5.53)]. We found that this relationship was not solely related to early-life SEP, adverse childhood experiences and young adulthood health status, behaviours and SEP [HR = 2.57 (1.59 to 4.15)]. Regarding the ability of each physiological system and biomarkers to predict future death, our results suggest that the cumulative measure was advantageous compared to evaluating each physiological system sub-score and biomarker separately. Our findings add some evidence of a biological embodiment in response to stress which ultimately affects mortality. The online version of this article (10.1007/s10654-018-0364-1) contains supplementary material, which is available to authorized users.
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影响因子：
2.9
作者：
Levine, Morgan E.;Crimmins, Eileen M.
通讯作者：
Crimmins, Eileen M.
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