The mitochondrial genome structure of Xenoturbella bocki (phylum Xenoturbellida) is ancestral within the deuterostomes.
The mitochondrial genome structure of Xenoturbella bocki (phylum Xenoturbellida) is ancestral within the deuterostomes.
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DOI：
10.1186/1471-2148-9-107
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发表时间：
2009-05-18
影响因子：
3.4
通讯作者：
Telford MJ
中科院分区：
文献类型：
--
作者：
Bourlat SJ;Rota-Stabelli O;Lanfear R;Telford MJ
线粒体基因组比较在推断动物关系时以多种方式做出贡献。除了一级序列数据，罕见的基因组变化，如基因顺序，共享的基因边界和遗传密码的变化，这是不太可能出现在收敛进化，是有用的工具，在解决深同源性。博基奇鳖虫是一种形态简单的底栖海洋蠕虫，最近被发现属于后口动物。在这里，我们目前的分析比较Xenoturbella bocki线粒体基因顺序，遗传密码和控制区的其他后生动物组。测定了包氏奇鳖的线粒体全基因组序列。基因顺序与脊索动物和半脊索动物的基因顺序最相似，表明这种保守的线粒体基因顺序可能是后口动物分支的祖先。使用数据从所有门的后口类，我们推断这支祖先的线粒体基因顺序。使用反转和断点分析后生动物的线粒体基因组，我们测试相互矛盾的假设Xenoturbella的系统发育位置，并发现一个更密切的亲和力比其他后生动物组的hemichordates。控制区的比较分析显示，在转录起始和终止位点和复制的脊椎动物的奇螟的起点的相似性。线粒体序列的系统发育分析表明，一个弱支持的位置作为一个基础后口，结果可能是成分偏见的影响。Xenoturbella bocki的线粒体基因组在后口组中具有非常保守的基因排列，与半脊索动物和脊索动物的基因排列惊人地相似，因此与祖先的后口基因顺序相似。通过倒置和断点分析，特别是半索动物的相似性。最后，虽然线粒体序列的系统发育分析支持一个基础的后口的位置，支持这减少了使用更复杂的序列进化模型。
Mitochondrial genome comparisons contribute in multiple ways when inferring animal relationships. As well as primary sequence data, rare genomic changes such as gene order, shared gene boundaries and genetic code changes, which are unlikely to have arisen through convergent evolution, are useful tools in resolving deep phylogenies. Xenoturbella bocki is a morphologically simple benthic marine worm recently found to belong among the deuterostomes. Here we present analyses comparing the Xenoturbella bocki mitochondrial gene order, genetic code and control region to those of other metazoan groups. The complete mitochondrial genome sequence of Xenoturbella bocki was determined. The gene order is most similar to that of the chordates and the hemichordates, indicating that this conserved mitochondrial gene order might be ancestral to the deuterostome clade. Using data from all phyla of deuterostomes, we infer the ancestral mitochondrial gene order for this clade. Using inversion and breakpoint analyses of metazoan mitochondrial genomes, we test conflicting hypotheses for the phylogenetic placement of Xenoturbella and find a closer affinity to the hemichordates than to other metazoan groups. Comparative analyses of the control region reveal similarities in the transcription initiation and termination sites and origin of replication of Xenoturbella with those of the vertebrates. Phylogenetic analyses of the mitochondrial sequence indicate a weakly supported placement as a basal deuterostome, a result that may be the effect of compositional bias. The mitochondrial genome of Xenoturbella bocki has a very conserved gene arrangement in the deuterostome group, strikingly similar to that of the hemichordates and the chordates, and thus to the ancestral deuterostome gene order. Similarity to the hemichordates in particular is suggested by inversion and breakpoint analysis. Finally, while phylogenetic analyses of the mitochondrial sequences support a basal deuterostome placement, support for this decreases with the use of more sophisticated models of sequence evolution.
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影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
从整个线粒体基因组序列推断出的鲸鱼腹部湖泊（头孢菌）的系统发育位置。
影响因子：
3.4
作者：
Kon, Takeshi;Nohara, Masahiro;Yamanoue, Yusuke;Fujiwara, Yoshihiro;Nishida, Mutsumi;Nishikawa, Teruaki
通讯作者：
Nishikawa, Teruaki
影响因子：
4.1
作者：
Knudsen, B;Kohn, AB;Moroz, LL
通讯作者：
Moroz, LL
影响因子：
14.9
作者：
Grillo, G;Licciulli, F;Pesole, G
通讯作者：
Pesole, G
影响因子：
10.7
作者：
Gibson, A;Gowri-Shankar, V;Rattray, M
通讯作者：
Rattray, M